PT  - JOURNAL ARTICLE
AU  - UEDA, SEI
AU  - GOTO, MITSUO
AU  - HASHIMOTO, KENGO
AU  - HASEGAWA, SHOGO
AU  - IMAZAWA, MASAHIKO
AU  - TAKAHASHI, MARICO
AU  - OH-IWA, ICHIRO
AU  - SHIMOZATO, KAZUO
AU  - NAGAO, TORU
AU  - NOMOTO, SHUJI
TI  - Salivary <em>CCL20</em> Level as a Biomarker for Oral Squamous Cell Carcinoma
AID  - 10.21873/cgp.20245
DP  - 2021 Mar 01
TA  - Cancer Genomics - Proteomics
PG  - 103--112
VI  - 18
IP  - 2
4099  - http://cgp.iiarjournals.org/content/18/2/103.short
4100  - http://cgp.iiarjournals.org/content/18/2/103.full
SO  - Cancer Genomics Proteomics2021 Mar 01; 18
AB  - Background/Aim: This study investigated the utility of C-C motif chemokine ligand 20 (CCL20) expression in saliva as a biomarker for oral squamous cell carcinoma (OSCC) and also examined the associated microbiome. Materials and Methods: The study group included patients with OSCC or oral potentially malignant disorder (OPMD), and healthy volunteers (HVs). microarray and qRT-PCR were used to compare salivary CCL20 expression levels among groups. Data on CCL20 levels in oral cancer tissues and normal tissues were retrieved from a public database and examined. Furthermore, next-generation sequencing was used to investigate the salivary microbiome. Results: A significant increase in the expression level of CCL20 was observed in both OSCC tissues and saliva from patients with oral cancer. Fusobacterium was identified as the predominant bacteria in OSCC and correlated with CCL20 expression level. OSCC screening based on salivary CCL20 expression enabled successful differentiation between patients with OSCC and HVs. Conclusion: CCL20 expression may be a useful biomarker for OSCC.