PT - JOURNAL ARTICLE AU - IOANNIS PANAGOPOULOS AU - KRISTIN ANDERSEN AU - MARTINE EILERT-OLSEN AU - ANNE GRO ROGNLIEN AU - MONICA CHENG MUNTHE-KAAS AU - FRANCESCA MICCI AU - SVERRE HEIM TI - Rare <em>KMT2A-ELL</em> and Novel <em>ZNF56-KMT2A</em> Fusion Genes in Pediatric T-cell Acute Lymphoblastic Leukemia AID - 10.21873/cgp.20247 DP - 2021 Mar 01 TA - Cancer Genomics - Proteomics PG - 121--131 VI - 18 IP - 2 4099 - http://cgp.iiarjournals.org/content/18/2/121.short 4100 - http://cgp.iiarjournals.org/content/18/2/121.full SO - Cancer Genomics Proteomics2021 Mar 01; 18 AB - Background/Aim: Previous reports have associated the KMT2A-ELL fusion gene, generated by t(11;19)(q23;p13.1), with acute myeloid leukemia (AML). We herein report a KMT2A-ELL and a novel ZNF56-KMT2A fusion genes in a pediatric T-lineage acute lymphoblastic leukemia (T-ALL). Materials and Methods: Genetic investigations were performed on bone marrow of a 13-year-old boy diagnosed with T-ALL. Results: A KMT2A-ELL and a novel ZNF56-KMT2A fusion genes were generated on der(11)t(11;19)(q23;p13.1) and der(19)t(11;19)(q23;p13.1), respectively. Exon 20 of KMT2A fused to exon 2 of ELL in KMT2A-ELL chimeric transcript whereas exon 1 of ZNF56 fused to exon 21 of KMT2A in ZNF56-KMT2A transcript. A literature search revealed four more T-ALL patients carrying a KMT2A-ELL fusion. All of them were males aged 11, 11, 17, and 20 years. Conclusion: KMT2A-ELL fusion is a rare recurrent genetic event in T-ALL with uncertain prognostic implications. The frequency and impact of ZNF56-KMT2A in T-ALL are unknown.