RT Journal Article SR Electronic T1 Proteomic Analysis of Pelvic Autonomic Nerve in Nerve-sparing Radical Hysterectomy for Cervical Carcinoma JF Cancer Genomics - Proteomics JO Cancer Genomics Proteomics FD International Institute of Anticancer Research SP 337 OP 342 DO 10.21873/cgp.20092 VO 15 IS 4 A1 YOON HEE LEE A1 MIN KYUNG KIM A1 HEE YOUNG MOON A1 GUN OH CHONG A1 HYUN JUNG LEE A1 YOON SOON LEE A1 JI YOUNG PARK A1 CHAN HYEONG LEE A1 MOON CHANG BAEK A1 DAE GY HONG YR 2018 UL http://cgp.iiarjournals.org/content/15/4/337.abstract AB Background/Aim: This study was designed to identify candidate proteins which can be used for visualization of pelvic autonomic nerve during nerve-sparing surgery. Materials and Methods: Both soft tissue and vesical branch of the inferior hypogastric nerve from five women were collected during surgery. These 10 tissue specimens were analysed using liquid chromatography–mass spectrometry (LC-MS) and Human Protein Atlas (HPA) for protein expression. The existence of nerve fibres was confirmed using haematoxylin and eosin (H&E) and anti-S-100 staining. Results: A total of 413 proteins were detected. There were three proteins (isoform 1 of fibronectin, protein S100-A8 and A9) which implied a relation with pelvic autonomic nerve. In nerve tissue from one case, the existence of nerve fibre was not confirmed. Conclusion: Further large studies are expected to present more nerve-specific candidate proteins which can be used for the easy and safe identification of autonomic nerves.