TY - JOUR T1 - The Association Between the Genetic <em>VDR</em> SNP c.907+75C&gt;T and Prostate Cancer Risk Is Modified by Tanning Potential JF - Cancer Genomics - Proteomics JO - Cancer Genomics Proteomics SP - 739 LP - 745 DO - 10.21873/cgp.20228 VL - 17 IS - 6 AU - DESTA A BEYENE AU - MOHAMMAD R. DAREMIPOURAN AU - VICTOR APPREY AU - TAMMEY NAAB AU - OLAKUNLE O. KASSIM AU - ROBERT L. COPELAND AU - YASMINE M. KANAAN Y1 - 2020/11/01 UR - http://cgp.iiarjournals.org/content/17/6/739.abstract N2 - Background: Prostate cancer (PCa) is a multifactorial disease involving complex interactions between genetic and physiological/environmental factors. Vitamin D receptor (VDR) plays a role in numerous cellular pathways and it has been suggested that VDR genetic variants influence individual susceptibility to PCa. Materials and Methods: Logistic regression analysis was used to assess the association of six VDR single nucleotide polymorphisms (SNPs) and factors such as tanning potential and UV sunlight exposure with PCa risk. Results: Marginal significant interactions were found, with a 2-fold increase risk of PCa between SNP 1 (c.278-69G&gt;A) and sunlight UV exposure [odds ratio (OR)=2.02, 95% confidence intervaI (CI)=1.036-4.36; p=0.05]; and a 4-fold increase risk of PCa between SNP 4 (c.907+75C&gt;T) and tanning potential (OR=4.40, 95% CI=0.89-29.12; p=0.0591). In contrast, SNP 5 (rs731236, TaqI) and tanning potential interaction had a protective effect by reducing the risk of PCa by 55% (β=−0.804; OR=0.448, 95% CI=0.197-9.42; p=0.0427). SNPs 2 (rs61614328) and 6 (rs533037428) did not show any association with PCa even in the presence of UV sunlight exposure. Conclusion: The protective effect of SNP 4 from PCa is lost and modified by tanning potential in African Americans. This finding needs to be verified by larger studies in different ethnic populations. ER -