PT  - JOURNAL ARTICLE
AU  - CHEN, LI-HSIOU
AU  - SHEN, TE-CHUN
AU  - LI, CHIA-HSIANG
AU  - CHIU, KUO-LIANG
AU  - HSIAU, YU-CHEN
AU  - WANG, YUN-CHI
AU  - GONG, CHI-LI
AU  - WANG, ZHI-HONG
AU  - CHANG, WEN-SHIN
AU  - TSAI, CHIA-WEN
AU  - HSIA, TE-CHUN
AU  - BAU, DA-TIAN
TI  - The Significant Interaction of Excision Repair Cross-complementing Group 1 Genotypes and Smoking to Lung Cancer Risk
AID  - 10.21873/cgp.20213
DP  - 2020 Sep 01
TA  - Cancer Genomics - Proteomics
PG  - 571--577
VI  - 17
IP  - 5
4099  - http://cgp.iiarjournals.org/content/17/5/571.short
4100  - http://cgp.iiarjournals.org/content/17/5/571.full
SO  - Cancer Genomics Proteomics2020 Sep 01; 17
AB  - Background: The study aims to evaluate the contribution of excision repair cross-complementing group 1 (ERCC1), which plays an important role in genome integrity maintenance, to lung cancer risk. Materials and Methods: ERCC1 rs11615 and rs3212986 genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism analysis and their association with lung cancer risk was examined among 358 lung cancer patients and 716 controls. Results: The proportions of CC, CT and TT for the rs11615 genotype were 43.6%, 41.6% and 14.8% in the case group and 50.0%, 41.1% and 8.9% in the control group, respectively (p for trend=0.0082). Allelic analysis showed that ERCC1 rs11615 T-allele carriers have a 1.32-fold higher risk of lung cancer than wild-type C-allele carriers [95%confidence interval (CI)=1.09-1.60, p=0.0039]. In addition, a significant interaction between the rs11615 genotype and smoking status was observed. Conclusion: The T allele of ERCC1 rs11615 jointly with smoking habits may contribute to a higher lung cancer risk in Taiwan.