%0 Journal Article %A LI-HSIOU CHEN %A TE-CHUN SHEN %A CHIA-HSIANG LI %A KUO-LIANG CHIU %A YU-CHEN HSIAU %A YUN-CHI WANG %A CHI-LI GONG %A ZHI-HONG WANG %A WEN-SHIN CHANG %A CHIA-WEN TSAI %A TE-CHUN HSIA %A DA-TIAN BAU %T The Significant Interaction of Excision Repair Cross-complementing Group 1 Genotypes and Smoking to Lung Cancer Risk %D 2020 %R 10.21873/cgp.20213 %J Cancer Genomics - Proteomics %P 571-577 %V 17 %N 5 %X Background: The study aims to evaluate the contribution of excision repair cross-complementing group 1 (ERCC1), which plays an important role in genome integrity maintenance, to lung cancer risk. Materials and Methods: ERCC1 rs11615 and rs3212986 genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism analysis and their association with lung cancer risk was examined among 358 lung cancer patients and 716 controls. Results: The proportions of CC, CT and TT for the rs11615 genotype were 43.6%, 41.6% and 14.8% in the case group and 50.0%, 41.1% and 8.9% in the control group, respectively (p for trend=0.0082). Allelic analysis showed that ERCC1 rs11615 T-allele carriers have a 1.32-fold higher risk of lung cancer than wild-type C-allele carriers [95%confidence interval (CI)=1.09-1.60, p=0.0039]. In addition, a significant interaction between the rs11615 genotype and smoking status was observed. Conclusion: The T allele of ERCC1 rs11615 jointly with smoking habits may contribute to a higher lung cancer risk in Taiwan. %U https://cgp.iiarjournals.org/content/cgp/17/5/571.full.pdf