<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">CHEN, LI-HSIOU</style></author><author><style face="normal" font="default" size="100%">SHEN, TE-CHUN</style></author><author><style face="normal" font="default" size="100%">LI, CHIA-HSIANG</style></author><author><style face="normal" font="default" size="100%">CHIU, KUO-LIANG</style></author><author><style face="normal" font="default" size="100%">HSIAU, YU-CHEN</style></author><author><style face="normal" font="default" size="100%">WANG, YUN-CHI</style></author><author><style face="normal" font="default" size="100%">GONG, CHI-LI</style></author><author><style face="normal" font="default" size="100%">WANG, ZHI-HONG</style></author><author><style face="normal" font="default" size="100%">CHANG, WEN-SHIN</style></author><author><style face="normal" font="default" size="100%">TSAI, CHIA-WEN</style></author><author><style face="normal" font="default" size="100%">HSIA, TE-CHUN</style></author><author><style face="normal" font="default" size="100%">BAU, DA-TIAN</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">The Significant Interaction of Excision Repair Cross-complementing Group 1 Genotypes and Smoking to Lung Cancer Risk</style></title><secondary-title><style face="normal" font="default" size="100%">Cancer Genomics - Proteomics</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2020-09-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">571-577</style></pages><doi><style  face="normal" font="default" size="100%">10.21873/cgp.20213</style></doi><volume><style face="normal" font="default" size="100%">17</style></volume><issue><style face="normal" font="default" size="100%">5</style></issue><abstract><style  face="normal" font="default" size="100%">Background: The study aims to evaluate the contribution of excision repair cross-complementing group 1 (ERCC1), which plays an important role in genome integrity maintenance, to lung cancer risk. Materials and Methods: ERCC1 rs11615 and rs3212986 genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism analysis and their association with lung cancer risk was examined among 358 lung cancer patients and 716 controls. Results: The proportions of CC, CT and TT for the rs11615 genotype were 43.6%, 41.6% and 14.8% in the case group and 50.0%, 41.1% and 8.9% in the control group, respectively (p for trend=0.0082). Allelic analysis showed that ERCC1 rs11615 T-allele carriers have a 1.32-fold higher risk of lung cancer than wild-type C-allele carriers [95%confidence interval (CI)=1.09-1.60, p=0.0039]. In addition, a significant interaction between the rs11615 genotype and smoking status was observed. Conclusion: The T allele of ERCC1 rs11615 jointly with smoking habits may contribute to a higher lung cancer risk in Taiwan.</style></abstract></record></records></xml>