TY - JOUR T1 - The Significant Interaction of Excision Repair Cross-complementing Group 1 Genotypes and Smoking to Lung Cancer Risk JF - Cancer Genomics - Proteomics JO - Cancer Genomics Proteomics SP - 571 LP - 577 DO - 10.21873/cgp.20213 VL - 17 IS - 5 AU - LI-HSIOU CHEN AU - TE-CHUN SHEN AU - CHIA-HSIANG LI AU - KUO-LIANG CHIU AU - YU-CHEN HSIAU AU - YUN-CHI WANG AU - CHI-LI GONG AU - ZHI-HONG WANG AU - WEN-SHIN CHANG AU - CHIA-WEN TSAI AU - TE-CHUN HSIA AU - DA-TIAN BAU Y1 - 2020/09/01 UR - http://cgp.iiarjournals.org/content/17/5/571.abstract N2 - Background: The study aims to evaluate the contribution of excision repair cross-complementing group 1 (ERCC1), which plays an important role in genome integrity maintenance, to lung cancer risk. Materials and Methods: ERCC1 rs11615 and rs3212986 genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism analysis and their association with lung cancer risk was examined among 358 lung cancer patients and 716 controls. Results: The proportions of CC, CT and TT for the rs11615 genotype were 43.6%, 41.6% and 14.8% in the case group and 50.0%, 41.1% and 8.9% in the control group, respectively (p for trend=0.0082). Allelic analysis showed that ERCC1 rs11615 T-allele carriers have a 1.32-fold higher risk of lung cancer than wild-type C-allele carriers [95%confidence interval (CI)=1.09-1.60, p=0.0039]. In addition, a significant interaction between the rs11615 genotype and smoking status was observed. Conclusion: The T allele of ERCC1 rs11615 jointly with smoking habits may contribute to a higher lung cancer risk in Taiwan. ER -