TY - JOUR T1 - Recurrent Fusion of the GRB2 Associated Binding Protein 1 (<em>GAB1</em>) Gene With ABL Proto-oncogene 1 (<em>ABL1</em>) in Benign Pediatric Soft Tissue Tumors JF - Cancer Genomics - Proteomics JO - Cancer Genomics Proteomics SP - 499 LP - 508 DO - 10.21873/cgp.20206 VL - 17 IS - 5 AU - IOANNIS PANAGOPOULOS AU - LUDMILA GORUNOVA AU - KRISTIN ANDERSEN AU - SVETLANA TAFJORD AU - MARIUS LUND-IVERSEN AU - INGVILD LOBMAIER AU - FRANCESCA MICCI AU - SVERRE HEIM Y1 - 2020/09/01 UR - http://cgp.iiarjournals.org/content/17/5/499.abstract N2 - Background/Aim: Fusions of the ABL proto-oncogene 1 gene (ABL1 in 9q34) are common in leukemias but rare in solid tumors. The most notable is the t(9;22)(q34;q11)/BCR-ABL1 coding for a chimeric tyrosine kinase. We herein report an ABL1-fusion in a pediatric tumor. Materials and Methods: G-banding, fluorescence in situ hybridization, reverse transcription polymerase chain reaction and Sanger sequencing were performed on a soft tissue perineurioma found in the left musculus erector spinae of a child. Results: A der(4)t(4;9)(q31;q34) and a fusion of the GRB2 associated binding protein 1 (GAB1 in 4q31) gene with ABL1 were found. A literature search revealed 3 more cases with similar genetic and clinicopathological characteristics: a soft tissue perineurioma with t(2;9;4)(p23;q34;q31) and ABL1 rearrangement, a soft tissue angiofibroma with a GAB1-ABL1 chimeric gene, and a solitary fibrous tumor carrying a der(4)t(4;9)(q31.1;q34). Conclusion: GAB1-ABL1 is a recurrent fusion gene in benign pediatric tumors. ER -