TY - JOUR T1 - Platinum Drug Sensitivity Polymorphisms in Stage III Non-small Cell Lung Cancer With Invasion of Mediastinal Lymph Nodes JF - Cancer Genomics - Proteomics JO - Cancer Genomics Proteomics SP - 587 LP - 595 DO - 10.21873/cgp.20215 VL - 17 IS - 5 AU - ANCA NASTASE AU - AUDREY LUPO AU - VICTORIA LASZLO AU - DIANE DAMOTTE AU - SIMONA DIMA AU - EMELYNE CANNY AU - MARCO ALIFANO AU - IRINEL POPESCU AU - WALTER KLEPETKO AU - MADALINA GRIGOROIU Y1 - 2020/09/01 UR - http://cgp.iiarjournals.org/content/17/5/587.abstract N2 - Background/Aim: Patients with stage IIIA (N2) non-small cell lung cancer (NSCLC) with no progression after induction chemotherapy are usually selected for surgery. Nowadays, response to chemotherapy is not predictable. We aimed to identify genomic predictive markers for response to induction chemotherapy in stage IIIA (N2) NSCLC patients. Patients and Methods: Whole-exome sequencing (WES) was performed on samples from 11 patients with no response after induction chemotherapy and 6 patients with documented pathological response, admitted to the Hotel Dieu Hospital, Paris or Allegemeines Krakenhaus University, Vienna. Results: A higher alternative allele frequency was found on SENP5, rs63736860, rs1602 and NCBP2, rs553783 in the non-responder group, and on RGP1, rs1570248, SLFN12L, rs2304968, rs9905892, and GBA2, rs3833700 in the responder group. Conclusion: These polymorphisms contribute to inter-individual sensibility to chemotherapy response. Interrogation of these genetic variations may have potential applicability when deciding the treatment strategy for patients with stage III NSCLC (N2). ER -