RT Journal Article
SR Electronic
T1 The Role of Circulating Adiponectin and SNP276G&gt;T at <em>ADIPOQ</em> Gene in <em>BRCA</em>-mutant Women
JF Cancer Genomics - Proteomics
JO Cancer Genomics Proteomics
FD International Institute of Anticancer Research
SP 301
OP 307
DO 10.21873/cgp.20190
VO 17
IS 3
A1 ANTONELLA DANIELE
A1 ANGELO VIRGILIO PARADISO
A1 ROSA DIVELLA
A1 MARIA DIGENNARO
A1 MARGHERITA PATRUNO
A1 STEFANIA TOMMASI
A1 BRUNELLA PILATO
A1 ANTONIO TUFARO
A1 MICHELE BARONE
A1 CARLA MINOIA
A1 DONATELLA COLANGELO
A1 EUFEMIA SAVINO
A1 PORZIA CASAMASSIMA
A1 ELEONORA BRUNO
A1 ANDREINA OLIVERIO
A1 PATRIZIA PASANISI
YR 2020
UL http://cgp.iiarjournals.org/content/17/3/301.abstract
AB Background: Environmental factors may influence the lifetime risk of cancer (penetrance) in women with a BRCA mutation. Materials and Methods: In 89 BRCA-mutant women, affected or unaffected by breast/ovarian cancer, we explored serum levels of adipokines and their relation with the polymorphism SNP276G&gt;T as modulators of BRCA penetrance. Results: Affected women had significantly lower adiponectin than healthy women. Affected women with rs1501299 TT had significantly lower adiponectin and higher leptin than GT and GG genotypes. GT genotype was significantly associated with the disease status [odds ratio (OR)=3.24, 95% confidence interval (95% CI)=1.03-10.17]. Women in the lower tertile of serum adiponectin had a RR of BRCA-associated cancer of 2.80, 95% CI=1.1-7.1 (p for trend=0.03) compared with women in the higher tertile. Conclusion: In the SNP rs1501299 the T allele was significantly associated with lower serum levels of adiponectin in affected women, suggesting that the T allele might be related to cancer.