TY - JOUR T1 - <em>NDRG1-PLAG1</em> and <em>TRPS1-PLAG1</em> Fusion Genes in Chondroid Syringoma JF - Cancer Genomics - Proteomics JO - Cancer Genomics Proteomics SP - 237 LP - 248 DO - 10.21873/cgp.20184 VL - 17 IS - 3 AU - IOANNIS PANAGOPOULOS AU - LUDMILA GORUNOVA AU - KRISTIN ANDERSEN AU - MARIUS LUND-IVERSEN AU - INGVILD LOBMAIER AU - FRANCESCA MICCI AU - SVERRE HEIM Y1 - 2020/05/01 UR - http://cgp.iiarjournals.org/content/17/3/237.abstract N2 - Background/Aim: Chondroid syringoma is a rare benign tumor emanating from sweat glands. Although rearrangements of the pleomorphic adenoma gene 1 (PLAG1) have been reported in such tumors, information on PLAG1 fusion genes is very limited. Materials and Methods: Cytogenetic, fluorescence in situ hybridization, RNA sequencing, array comparative genomic hybridization, reverse transcription polymerase chain reaction, and Sanger sequencing analyses were performed on two chondroid syringoma cases. Results: Both tumors had structural rearrangements of chromosome 8. An NDRG1-PLAG1 transcript was found in the first tumor in which exon 3 of PLAG1 was fused with exon 1 of NDRG1. A TRPS1-PLAG1 chimeric transcript was detected in the second chondroid syringoma in which exon 2 or exon 3 of PLAG1 was fused with exon 1 of TRPS1. Conclusion: The NDRG1-PLAG1 and TRPS1-PLAG1 resemble other PLAG1 fusion genes inasmuch as the expression of PLAG1 comes under the control of the NDRG1 or TRPS1 promoter. ER -