TY - JOUR T1 - Genetic Association Analysis of Cell Cycle Regulators Reveals <em>YWHAZ</em> Has Prognostic Significance in Prostate Cancer JF - Cancer Genomics - Proteomics JO - Cancer Genomics Proteomics SP - 209 LP - 216 DO - 10.21873/cgp.20181 VL - 17 IS - 2 AU - CHIA-CHENG YU AU - LIH-CHYANG CHEN AU - WEN-HSIN LIN AU - VICTOR C. LIN AU - CHAO-YUAN HUANG AU - TE-LING LU AU - CHENG-HSUEH LEE AU - SHU-PIN HUANG AU - BO-YING BAO Y1 - 2020/03/01 UR - http://cgp.iiarjournals.org/content/17/2/209.abstract N2 - Background/Aim: This study aimed to identify the genes that cause biochemical recurrence (BCR) following radical prostatectomy (RP) in men with localized prostate cancer. Patients and Methods: A two-stage genetic association study of 19 single-nucleotide polymorphisms in 11 key cell cycle regulation genes was carried out. BCR-free survival after RP was evaluated in a discovery cohort of 458 patients with prostate cancer, and replication was investigated in another cohort of 185 patients. Results: A consistent association was found between BCR and rs2290291 (discovery: p=0.008; replication: p=0.029). rs2290291 is located in the tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ), and was predicted to possess a regulatory function that affected YWHAZ expression. Furthermore, YWHAZ expression was frequently up-regulated in advanced tumours, and associated with poorer survival in patients with prostate cancer. Conclusion: YWHAZ rs2290291 was found to be associated with BCR. YWHAZ may function as a putative oncogene during prostate cancer progression. ER -