RT Journal Article
SR Electronic
T1 Significant Association Between the MiR146a Genotypes and Susceptibility to Childhood Acute Lymphoblastic Leukemia in Taiwan
JF Cancer Genomics - Proteomics
JO Cancer Genomics Proteomics
FD International Institute of Anticancer Research
SP 175
OP 180
DO 10.21873/cgp.20178
VO 17
IS 2
A1 PEI, JEN-SHENG
A1 CHANG, WEN-SHIN
A1 HSU, PEI-CHEN
A1 CHEN, CHAO-CHUN
A1 CHIN, YU-TING
A1 HUANG, TAI-LIN
A1 HSU, YUAN-NIAN
A1 KUO, CHIEN-CHUNG
A1 WANG, YUN-CHI
A1 TSAI, CHIA-WEN
A1 GONG, CHI-LI
A1 BAU, DA-TIAN
YR 2020
UL http://cgp.iiarjournals.org/content/17/2/175.abstract
AB Background/Aim: Mounting evidence has shown that miRNAs play a critical role in the regulation of hematopoiesis of cell proliferation and apoptosis as well as in tumorigenesis. The miR146a rs2910164 polymorphism, which is closely responsive for its expression, has been reported to associate with the risk of several solid cancers. The study aimed at examining the association of the it with susceptibility to childhood acute lymphoblastic leukemia (ALL) in Taiwan. Materials and Methods: We recruited 266 patients with childhood ALL and 266 healthy controls, and rs2910164 genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism methodology. Results: The allele G was associated with decreased childhood ALL risk (OR=0.66, 95%CI=0.52-0.85, p=0.0011). Consistently, the GG genotype was associated with a decreased susceptibility (OR=0.40, 95%CI=0.23-0.67, p=0.0004). Patients with CG and GG genotypes were of earlier onset than those with CC genotype (p=0.0255 and p=0.0001). Conclusion: MiR146a rs2910164 G allele serves as a protective marker for childhood ALL in Taiwan.