RT Journal Article
SR Electronic
T1 KIF15 Expression in Tumor-associated Monocytes Is a Prognostic Biomarker in Hepatocellular Carcinoma
JF Cancer Genomics - Proteomics
JO Cancer Genomics Proteomics
FD International Institute of Anticancer Research
SP 141
OP 149
DO 10.21873/cgp.20174
VO 17
IS 2
A1 KITAGAWA, AKIHIRO
A1 MASUDA, TAKAAKI
A1 TAKAHASHI, JUNICHI
A1 TOBO, TARO
A1 NODA, MIWA
A1 KURODA, YOSUKE
A1 HU, QINGJIANG
A1 KOUYAMA, YUTA
A1 KOBAYASHI, YUTA
A1 KURAMITSU, SHOTARO
A1 SATO, KUNIAKI
A1 FUJII, ATSUSHI
A1 YOSHIKAWA, YUKIHIRO
A1 WAKIYAMA, HIROAKI
A1 SHIMIZU, DAI
A1 TSURUDA, YUSUKE
A1 EGUCHI, HIDETOSHI
A1 DOKI, YUICHIRO
A1 MORI, MASAKI
A1 MIMORI, KOSHI
YR 2020
UL http://cgp.iiarjournals.org/content/17/2/141.abstract
AB Background/Aim: Kinesin family member 15 (KIF15) participates in the transport of macromolecules in essential cellular processes. In this study we evaluated the clinical relevance of KIF15 expression in hepatocellular carcinoma (HCC). Materials and Methods: Association between KIF15 expression and clinical outcomes in HCC patients was analyzed using three independent cohorts. Localization of KIF15 expression was assessed by immunohistochemical analysis. Co-culture experiments were performed using healthy donor peripheral blood mononuclear cells (PBMC) and HCC cell lines. Results: Immunohistochemical analysis showed that KIF15 was mainly expressed in inflammatory monocytes around cancer cells. Multivariate analysis indicated high KIF15 expression was an independent poor prognostic factor for survival. HCC cells with high expression of minichromosome maintenance protein 2 (MCM2) were located close to KIF15-expressing inflammatory monocytes. The proliferation ability of HCC cells was increased by co-culture with PBMC. Conclusion: High KIF15 expression in inflammatory monocytes in tumor tissues may serve as a prognostic marker for poor outcome in HCC.