RT Journal Article
SR Electronic
T1 KIF15 Expression in Tumor-associated Monocytes Is a Prognostic Biomarker in Hepatocellular Carcinoma
JF Cancer Genomics - Proteomics
JO Cancer Genomics Proteomics
FD International Institute of Anticancer Research
SP 141
OP 149
DO 10.21873/cgp.20174
VO 17
IS 2
A1 AKIHIRO KITAGAWA
A1 TAKAAKI MASUDA
A1 JUNICHI TAKAHASHI
A1 TARO TOBO
A1 MIWA NODA
A1 YOSUKE KURODA
A1 QINGJIANG HU
A1 YUTA KOUYAMA
A1 YUTA KOBAYASHI
A1 SHOTARO KURAMITSU
A1 KUNIAKI SATO
A1 ATSUSHI FUJII
A1 YUKIHIRO YOSHIKAWA
A1 HIROAKI WAKIYAMA
A1 DAI SHIMIZU
A1 YUSUKE TSURUDA
A1 HIDETOSHI EGUCHI
A1 YUICHIRO DOKI
A1 MASAKI MORI
A1 KOSHI MIMORI
YR 2020
UL http://cgp.iiarjournals.org/content/17/2/141.abstract
AB Background/Aim: Kinesin family member 15 (KIF15) participates in the transport of macromolecules in essential cellular processes. In this study we evaluated the clinical relevance of KIF15 expression in hepatocellular carcinoma (HCC). Materials and Methods: Association between KIF15 expression and clinical outcomes in HCC patients was analyzed using three independent cohorts. Localization of KIF15 expression was assessed by immunohistochemical analysis. Co-culture experiments were performed using healthy donor peripheral blood mononuclear cells (PBMC) and HCC cell lines. Results: Immunohistochemical analysis showed that KIF15 was mainly expressed in inflammatory monocytes around cancer cells. Multivariate analysis indicated high KIF15 expression was an independent poor prognostic factor for survival. HCC cells with high expression of minichromosome maintenance protein 2 (MCM2) were located close to KIF15-expressing inflammatory monocytes. The proliferation ability of HCC cells was increased by co-culture with PBMC. Conclusion: High KIF15 expression in inflammatory monocytes in tumor tissues may serve as a prognostic marker for poor outcome in HCC.