PT  - JOURNAL ARTICLE
AU  - KITAGAWA, AKIHIRO
AU  - MASUDA, TAKAAKI
AU  - TAKAHASHI, JUNICHI
AU  - TOBO, TARO
AU  - NODA, MIWA
AU  - KURODA, YOSUKE
AU  - HU, QINGJIANG
AU  - KOUYAMA, YUTA
AU  - KOBAYASHI, YUTA
AU  - KURAMITSU, SHOTARO
AU  - SATO, KUNIAKI
AU  - FUJII, ATSUSHI
AU  - YOSHIKAWA, YUKIHIRO
AU  - WAKIYAMA, HIROAKI
AU  - SHIMIZU, DAI
AU  - TSURUDA, YUSUKE
AU  - EGUCHI, HIDETOSHI
AU  - DOKI, YUICHIRO
AU  - MORI, MASAKI
AU  - MIMORI, KOSHI
TI  - KIF15 Expression in Tumor-associated Monocytes Is a Prognostic Biomarker in Hepatocellular Carcinoma
AID  - 10.21873/cgp.20174
DP  - 2020 Mar 01
TA  - Cancer Genomics - Proteomics
PG  - 141--149
VI  - 17
IP  - 2
4099  - http://cgp.iiarjournals.org/content/17/2/141.short
4100  - http://cgp.iiarjournals.org/content/17/2/141.full
SO  - Cancer Genomics Proteomics2020 Mar 01; 17
AB  - Background/Aim: Kinesin family member 15 (KIF15) participates in the transport of macromolecules in essential cellular processes. In this study we evaluated the clinical relevance of KIF15 expression in hepatocellular carcinoma (HCC). Materials and Methods: Association between KIF15 expression and clinical outcomes in HCC patients was analyzed using three independent cohorts. Localization of KIF15 expression was assessed by immunohistochemical analysis. Co-culture experiments were performed using healthy donor peripheral blood mononuclear cells (PBMC) and HCC cell lines. Results: Immunohistochemical analysis showed that KIF15 was mainly expressed in inflammatory monocytes around cancer cells. Multivariate analysis indicated high KIF15 expression was an independent poor prognostic factor for survival. HCC cells with high expression of minichromosome maintenance protein 2 (MCM2) were located close to KIF15-expressing inflammatory monocytes. The proliferation ability of HCC cells was increased by co-culture with PBMC. Conclusion: High KIF15 expression in inflammatory monocytes in tumor tissues may serve as a prognostic marker for poor outcome in HCC.