RT Journal Article SR Electronic T1 DNA Replication Inhibitor Geminin and Retinoic Acid Signaling Participate in Complex Interactions Associated With Pluripotency JF Cancer Genomics - Proteomics JO Cancer Genomics Proteomics FD International Institute of Anticancer Research SP 593 OP 601 DO 10.21873/cgp.20162 VO 16 IS 6 A1 SPYRIDON CHAMPERIS TSANIRAS A1 GEORGE J. DELINASIOS A1 MICHALIS PETROPOULOS A1 ANDREAS PANAGOPOULOS A1 ATHANASIOS K. ANAGNOSTOPOULOS A1 MARIA VILLIOU A1 DIMITRIOS VLACHAKIS A1 VASILIKI BRAVOU A1 GEORGIOS T. STATHOPOULOS A1 STAVROS TARAVIRAS YR 2019 UL http://cgp.iiarjournals.org/content/16/6/593.abstract AB Background/Aim: Several links between DNA replication, pluripotency and development have been recently identified. The involvement of miRNA in the regulation of cell cycle events and pluripotency factors has also gained attention. Materials and Methods: In the present study, we used the g:Profiler platform to analyze transcription factor binding sites, miRNA networks and protein-protein interactions to identify novel links among the aforementioned processes. Results and Conclusion: A complex circuitry between retinoic acid signaling, SWI/SNF components, pluripotency factors including Oct4, Sox2 and Nanog and cell cycle regulators was identified. It is suggested that the DNA replication inhibitor geminin plays a central role in this circuitry.