PT - JOURNAL ARTICLE AU - SPYRIDON CHAMPERIS TSANIRAS AU - GEORGE J. DELINASIOS AU - MICHALIS PETROPOULOS AU - ANDREAS PANAGOPOULOS AU - ATHANASIOS K. ANAGNOSTOPOULOS AU - MARIA VILLIOU AU - DIMITRIOS VLACHAKIS AU - VASILIKI BRAVOU AU - GEORGIOS T. STATHOPOULOS AU - STAVROS TARAVIRAS TI - DNA Replication Inhibitor Geminin and Retinoic Acid Signaling Participate in Complex Interactions Associated With Pluripotency AID - 10.21873/cgp.20162 DP - 2019 Nov 01 TA - Cancer Genomics - Proteomics PG - 593--601 VI - 16 IP - 6 4099 - http://cgp.iiarjournals.org/content/16/6/593.short 4100 - http://cgp.iiarjournals.org/content/16/6/593.full SO - Cancer Genomics Proteomics2019 Nov 01; 16 AB - Background/Aim: Several links between DNA replication, pluripotency and development have been recently identified. The involvement of miRNA in the regulation of cell cycle events and pluripotency factors has also gained attention. Materials and Methods: In the present study, we used the g:Profiler platform to analyze transcription factor binding sites, miRNA networks and protein-protein interactions to identify novel links among the aforementioned processes. Results and Conclusion: A complex circuitry between retinoic acid signaling, SWI/SNF components, pluripotency factors including Oct4, Sox2 and Nanog and cell cycle regulators was identified. It is suggested that the DNA replication inhibitor geminin plays a central role in this circuitry.