PT - JOURNAL ARTICLE AU - ROSA DIVELLA AU - ANTONELLA DANIELE AU - RAFFAELE DE LUCA AU - ANTONIO MAZZOCCA AU - EUSTACHIO RUGGIERI AU - EUFEMIA SAVINO AU - PORZIA CASAMASSIMA AU - MICHELE SIMONE AU - CARLO SABBA AU - ANGELO PARADISO TI - Synergism of Adipocytokine Profile and <em>ADIPOQ/TNF-α</em> Polymorphisms in NAFLD-associated MetS Predict Colorectal Liver Metastases Outgrowth AID - 10.21873/cgp.20154 DP - 2019 Nov 01 TA - Cancer Genomics - Proteomics PG - 519--530 VI - 16 IP - 6 4099 - http://cgp.iiarjournals.org/content/16/6/519.short 4100 - http://cgp.iiarjournals.org/content/16/6/519.full SO - Cancer Genomics Proteomics2019 Nov 01; 16 AB - Background/Aim: The aim of this study was to evaluate whether the altered profile of adipocytokine and genetic fingerprint in NAFLD-associated metabolic syndrome “cluster” represents synergistic risk factors predicting onset of liver colorectal cancer metastases. Materials and Methods: A total of 165 colorectal cancer patients were enrolled, 56,3% were with metabolic syndrome/NAFLD. Serum samples were assayed for ADIPOQ, leptin and TNF-a levels by ELISA. ADIPOQ rs266729 C/G and TNF-308 A/G genotypes were analyzed in DNA isolated from whole blood. Results: Reduction in adiponectin levels and increase in leptin and TNF-α was shown in patients with liver metastases. This trend was influenced by BMI, MetS/NAFLD, and insulin resistance. ADIPOQ G rs266729 and TNF- 308 A allele are associated with obesity, MetS/NAFLD and insulin resistance. ADIPOQ CG/GG and GA/AA TNF-alpha genotypes confer susceptibility to liver metastases. Conclusion: Obesity and hepatic steatosis significantly favor the development of colorectal cancer liver metastases and the individual adipocytokines genetic profile may play an important predictive role.