TY - JOUR T1 - Potential of Protein-based Anti-metastatic Therapy with Serpins and Inter α-Trypsin Inhibitors JF - Cancer Genomics - Proteomics JO - Cancer Genomics Proteomics SP - 225 LP - 238 DO - 10.21873/cgp.20081 VL - 15 IS - 4 AU - ULRICH H. WEIDLE AU - FABIAN BIRZELE AU - GEORG TIEFENTHALER Y1 - 2018/07/01 UR - http://cgp.iiarjournals.org/content/15/4/225.abstract N2 - In this review we summarize the principles of anti-metastatic therapy with selected serpin family proteins, such as pigment epithelial-derived factor (PEDF) and maspin, as well as inter α-trypsin inhibitor (IαIs) light chains (bikunin) and heavy chains (ITIHs). Case-by-case, antimetastatic activity may be dependent or independent of the protease-inhibitory activity of the corresponding proteins. We discuss the incidence of target deregulation in different tumor entities, mechanisms of deregulation, context-dependent functional issues as well as in vitro and in vivo target validation studies with transfected tumor cells or recombinant protein as anti-metastatic agents. Finally, we comment on possible clinical evaluation of these proteins in adjuvant therapy. ER -