%0 Journal Article %A ULRICH H. WEIDLE %A FABIAN BIRZELE %A GEORG TIEFENTHALER %T Potential of Protein-based Anti-metastatic Therapy with Serpins and Inter α-Trypsin Inhibitors %D 2018 %R 10.21873/cgp.20081 %J Cancer Genomics - Proteomics %P 225-238 %V 15 %N 4 %X In this review we summarize the principles of anti-metastatic therapy with selected serpin family proteins, such as pigment epithelial-derived factor (PEDF) and maspin, as well as inter α-trypsin inhibitor (IαIs) light chains (bikunin) and heavy chains (ITIHs). Case-by-case, antimetastatic activity may be dependent or independent of the protease-inhibitory activity of the corresponding proteins. We discuss the incidence of target deregulation in different tumor entities, mechanisms of deregulation, context-dependent functional issues as well as in vitro and in vivo target validation studies with transfected tumor cells or recombinant protein as anti-metastatic agents. Finally, we comment on possible clinical evaluation of these proteins in adjuvant therapy. %U https://cgp.iiarjournals.org/content/cgp/15/4/225.full.pdf