PT  - JOURNAL ARTICLE
AU  - YUEH, TE-CHENG
AU  - WU, CHENG-NAN
AU  - HUNG, YI-WEN
AU  - CHANG, WEN-SHIN
AU  - FU, CHUN-KAI
AU  - PEI, JEN-SHENG
AU  - WU, MING-HSIEN
AU  - LAI, YI-LIANG
AU  - LEE, YI-MIN
AU  - YEN, SHIOU-TING
AU  - LI, HSIN-TING
AU  - TSAI, CHIA-WEN
AU  - BAU, DA-TIAN
TI  - The Contribution of <em>MMP-7</em> Genotypes to Colorectal Cancer Susceptibility in Taiwan
DP  - 2018 May 01
TA  - Cancer Genomics - Proteomics
PG  - 207--212
VI  - 15
IP  - 3
4099  - http://cgp.iiarjournals.org/content/15/3/207.short
4100  - http://cgp.iiarjournals.org/content/15/3/207.full
SO  - Cancer Genomics Proteomics2018 May 01; 15
AB  - Background/Aim: Matrix metalloproteinases (MMPs) play important roles in inflammation and carcinogenesis, but the genotypic role of MMP-7 has never been investigated in colorectal cancer (CRC) among the Taiwanese. Therefore, in this study we aimed to evaluate the contribution of MMP-7 genotypes to the risk of CRC in Taiwan. Materials and Methods: In this case-control study, MMP-7 A-181G and C-153T promoter genotypes were determined and their association with CRC risk were investigated among 362 CRC patients and 362 age- and gender-matched healthy controls. In addition, the interaction of MMP-7 genotypes and personal behaviors were also examined. Results: The percentages of variant AG and GG for MMP-7 A-181G genotypes were 10.5% and 1.7% in the CRC group and 11.9% and 2.2% in the control group, respectively (p for trend=0.7145). The allelic frequency distribution analysis showed that the variant G allele of MMP-7 A-181G conferred a slight but non-significant decreased CRC susceptibility to the wild-type C allele (odds ratio (OR)=0.86, 95% confidence interval (CI)=0.64-1.31, p=0.37). Taiwanese all harbour the CC genotype at MMP-7 C-153T. As for the gene–lifestyle interaction, there were no obvious joint effects of MMP-7 A-181G genotype on the risk of CRC among ever smoker, alcohol drinker, non-smoker or non-drinker subgroups. No statistically significant correlation was observed between MMP-7 A-181G genotypic distributions and age, gender, tumor size, location or metastasis status. Conclusion: The genotypes of MMP-7 A-181G may play an indirect role in determining personal susceptibility to CRC and prognosis. The further genotyping work on MMP-7 and other genes (such as other MMPs, oncogenes and tumor suppression genes) on CRC susceptibility and prognosis, should be taken into consideration spontaneously in the precision medicine era.