RT Journal Article SR Electronic T1 Fusion of the Genes WWTR1 and FOSB in Pseudomyogenic Hemangioendothelioma JF Cancer Genomics - Proteomics JO Cancer Genomics Proteomics FD International Institute of Anticancer Research SP 293 OP 298 DO 10.21873/cgp.20134 VO 16 IS 4 A1 IOANNIS PANAGOPOULOS A1 INGVILD LOBMAIER A1 LUDMILA GORUNOVA A1 SVERRE HEIM YR 2019 UL http://cgp.iiarjournals.org/content/16/4/293.abstract AB Background/Aim: Pseudomyogenic hemangioendothelioma is a rare endothelial tumor. Previous genetic investigations have shown that the tumors carry either a SERPINE1-FOSB or an ACTB-FOSB fusion gene. The aim of the study was to identify FOSB fusions linked with pseudomyogenic hemangioendothelioma. Materials and Methods: RNA sequencing, reverse transcription polymerase chain reaction (RT-PCR) and Sanger sequencing analyses were performed on a pseudomyogenic hemangioendothelioma. Results: An in-frame fusion was found between exon 4 of WWTR1 from 3q25 and exon 2 of FOSB from 19q13. The fusion gene not only places FOSB under the control of the WWTR1 promoter, but is predicted to encode a chimeric WWTR1-FOSB transcription factor. Conclusion: FOSB may be fused with SERPINE1, ACTB, or WWTR1 in pseudomyogenic hemangioendotheliomas. The resulting overexpression of FOSB fusion is a potentially useful marker that could be helpful in the diagnosis of these tumors.