RT Journal Article
SR Electronic
T1 The Multiple Roles of Exosomes in Metastasis
JF Cancer Genomics - Proteomics
JO Cancer Genomics Proteomics
FD International Institute of Anticancer Research
SP 1
OP 15
VO 14
IS 1
A1 ULRICH H. WEIDLE
A1 FABIAN BIRZELE
A1 GWEN KOLLMORGEN
A1 RÜDIGER RÜGER
YR 2017
UL http://cgp.iiarjournals.org/content/14/1/1.abstract
AB Exosomes are important contributors to cell–cell communication and their role as diagnostic markers for cancer and the pathogenesis for cancer is under intensive investigation. Here, we focus on their role in metastasis-related processes. We discuss their impact regarding promotion of invasion and migration of tumor cells, conditioning of lymph nodes, generation of premetastatic niches and organotropism of metastasis. Furthermore, we highlight interactions of exosomes with bone marrow and stromal components such as fibroblasts, endothelial cells, myeloid- and other immune-related cells in the context of metastases. For all processes as described above, we outline molecular and cellular components for therapeutic intervention with metastatic processes.