RT Journal Article
SR Electronic
T1 Human Uterine Cervical Stromal Stem Cells (hUCESCs): Why and How they Exert their Antitumor Activity
JF Cancer Genomics - Proteomics
JO Cancer Genomics Proteomics
FD International Institute of Anticancer Research
SP 331
OP 337
VO 13
IS 5
A1 SCHNEIDER, JOSÉ
A1 EIRÓ, NOEMÍ
A1 PÉREZ-FERNÁNDEZ, ROMÁN
A1 MARTÍNEZ-ORDÓÑEZ, ANXO
A1 VIZOSO, FRANCISCO
YR 2016
UL http://cgp.iiarjournals.org/content/13/5/331.abstract
AB Our research team has recently isolated and characterized a new stromal stem cell line (hUCESCs) obtained from cytological smears, as routinely performed for cervical cancer screening. We have, furthermore, described that both hUCESCs directly, as well as the secretome contained in the conditioned medium used for growing them (hUCESCs-CM) have potent antitumoral, anti-inflammatory, antibiotic, antimycotic and re-epitheliasation-enhancing properties. The scientific explanation our team proposes for these pleiotropic effects are directly related to the site of origin of hUCESCs, the human cervical transition zone, which has unique features that biologically justify the different actions of hUCESCs and hUCESCs-CM. We, herein, expose our working theory for the biological activity of hUCESCs and hUCESCs-CM.