PT - JOURNAL ARTICLE AU - JOSÉ SCHNEIDER AU - NOEMÍ EIRÓ AU - ROMÁN PÉREZ-FERNÁNDEZ AU - ANXO MARTÍNEZ-ORDÓÑEZ AU - FRANCISCO VIZOSO TI - Human Uterine Cervical Stromal Stem Cells (hUCESCs): Why and How they Exert their Antitumor Activity DP - 2016 Sep 01 TA - Cancer Genomics - Proteomics PG - 331--337 VI - 13 IP - 5 4099 - http://cgp.iiarjournals.org/content/13/5/331.short 4100 - http://cgp.iiarjournals.org/content/13/5/331.full SO - Cancer Genomics Proteomics2016 Sep 01; 13 AB - Our research team has recently isolated and characterized a new stromal stem cell line (hUCESCs) obtained from cytological smears, as routinely performed for cervical cancer screening. We have, furthermore, described that both hUCESCs directly, as well as the secretome contained in the conditioned medium used for growing them (hUCESCs-CM) have potent antitumoral, anti-inflammatory, antibiotic, antimycotic and re-epitheliasation-enhancing properties. The scientific explanation our team proposes for these pleiotropic effects are directly related to the site of origin of hUCESCs, the human cervical transition zone, which has unique features that biologically justify the different actions of hUCESCs and hUCESCs-CM. We, herein, expose our working theory for the biological activity of hUCESCs and hUCESCs-CM.