<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">TSOUMAS, DIMITRIOS</style></author><author><style face="normal" font="default" size="100%">NIKOU, SOFIA</style></author><author><style face="normal" font="default" size="100%">GIANNOPOULOU, EFSTATHIA</style></author><author><style face="normal" font="default" size="100%">TSANIRAS, SPYRIDON CHAMPERIS</style></author><author><style face="normal" font="default" size="100%">SIRINIAN, CHAIDO</style></author><author><style face="normal" font="default" size="100%">MAROULIS, IOANNIS</style></author><author><style face="normal" font="default" size="100%">TARAVIRAS, STAVROS</style></author><author><style face="normal" font="default" size="100%">ZOLOTA, VASSILIKI</style></author><author><style face="normal" font="default" size="100%">KALOFONOS, HARALABOS P.</style></author><author><style face="normal" font="default" size="100%">BRAVOU, VASILIKI</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">ILK Expression in Colorectal Cancer Is Associated with EMT, Cancer Stem Cell Markers and Chemoresistance</style></title><secondary-title><style face="normal" font="default" size="100%">Cancer Genomics - Proteomics</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2018-03-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">127-141</style></pages><volume><style face="normal" font="default" size="100%">15</style></volume><issue><style face="normal" font="default" size="100%">2</style></issue><abstract><style  face="normal" font="default" size="100%">Background/Aim: Epithelial-mesenchymal transition (EMT) and cancer stem cells (CSC) are critically implicated in cancer metastasis and chemoresistance. Herein, we investigated integrin-linked kinase (ILK)'s role in human colon cancer (CRC) progression and chemoresistance in relation to EMT and CSC markers. Patients and Methods: Expression of ILK, EMT and CSC markers were evaluated by immunohistochemistry in 149 CRC samples. We also generated colon cancer cells resistant to 5-FU and oxaliplatin and studied the effect of ILK inhibition on drug response by MTT assay and on EMT and CSC markers' expression. Results: ILK expression in human CRC correlates with EMT and CSC markers and is associated with metastasis and chemoresistance. ILK inhibition increases sensitivity of resistant cells to 5-FU and oxaliplatin and reduces the levels of EMT and CSC markers in 5-FU resistant cells. Conclusion: ILK overexpression in human CRC associates with EMT and CSC traits, contributing to tumor progression and chemoresistance.</style></abstract></record></records></xml>