TY - JOUR T1 - Expression of Genes with Copy Number Alterations and Survival of Patients with Pancreatic Adenocarcinoma JF - Cancer Genomics - Proteomics JO - Cancer Genomics Proteomics SP - 191 LP - 200 VL - 13 IS - 3 AU - DAVID J. BIRNBAUM AU - FRANÇOIS BERTUCCI AU - PASCAL FINETTI AU - JOSÉ ADÉLAÏDE AU - MARC GIOVANNINI AU - OLIVIER TURRINI AU - JEAN ROBERT DELPERO AU - JEAN LUC RAOUL AU - MAX CHAFFANET AU - VINCENT MOUTARDIER AU - DANIEL BIRNBAUM AU - EMILIE MAMESSIER Y1 - 2016/05/01 UR - http://cgp.iiarjournals.org/content/13/3/191.abstract N2 - Background/Aim: Individual molecular information might improve management of pancreatic adenocarcinoma. To identify actionable genes, at the transcriptional level, we investigated candidate genes that we had previously identified using array-comparative genomic hybridization (aCGH). Materials and Methods: We collected 10 public gene-expression datasets, gathering a total of 524 pancreatic samples (105 normal and 419 malignant tissues). Based on our previous aCGH analysis, we searched for genes differentially expressed between normal and malignant samples and genes associated with survival. Results: Among genes amplified/gained by aCGH, 48% were overexpressed in malignant tissues. The majority of these genes were related to apoptosis, cell-cycle regulation and differentiation. Among genes located in areas of loss, 41% were underexpressed in malignant tissues; most of them were involved in ion transport, homeostasis maintenance and fatty acid metabolism. Survival analysis identified genes significantly related to shorter (n=17) or longer (n=29) survival. Conclusion: Some of these genes can be further investigated as potential prognostic markers. ER -