RT Journal Article SR Electronic T1 Data-driven Analysis of TRP Channels in Cancer: Linking Variation in Gene Expression to Clinical Significance JF Cancer Genomics - Proteomics JO Cancer Genomics Proteomics FD International Institute of Anticancer Research SP 83 OP 90 VO 13 IS 1 A1 YU RANG PARK A1 JUNG NYEO CHUN A1 INSUK SO A1 HWA JUNG KIM A1 SEUNGHEE BAEK A1 JU-HONG JEON A1 SOO-YONG SHIN YR 2016 UL http://cgp.iiarjournals.org/content/13/1/83.abstract AB Background: Experimental evidence has suggested that transient receptor potential (TRP) channels play a crucial role in tumor biology. However, clinical relevance and significance of TRP channels in cancer remain largely unknown. Materials and Methods: We applied a data-driven approach to dissect the expression landscape of 27 TRP channel genes in 14 types of human cancer using International Cancer Genome Consortium data. Results: TRPM2 was found overexpressed in most tumors, whereas TRPM3 was broadly down-regulated. TRPV4 and TRPA1 were found up- and down-regulated respectively in a cancer type-specific manner. TRPC4 was found to be closely associated with incidence of head and neck cancer and poor survival of patients with kidney cancer. TRPM8 was identified as a new molecular marker for lung cancer diagnosis and TRPP1 for kidney cancer prognosis. Conclusion: Our data-driven approach demonstrates that the variation in the expression of TRP channel genes is manifested across various human cancer types and genes, for certain TRP channels have strong predictive diagnostic and prognostic potential.