TY - JOUR T1 - Colitic Cancer Develops Through Mutational Alteration Distinct from that in Sporadic Colorectal Cancer: A Comparative Analysis of Mutational Rates at Each Step JF - Cancer Genomics - Proteomics JO - Cancer Genomics Proteomics SP - 341 LP - 348 VL - 14 IS - 5 AU - TOSHIAKI TANAKA AU - TAKASHI KOBUNAI AU - YOKO YAMAMOTO AU - SHIGENOBU EMOTO AU - KOJI MURONO AU - MANABU KANEKO AU - KAZUHITO SASAKI AU - KENSUKE OTANI AU - TAKESHI NISHIKAWA AU - KAZUSHIGE KAWAI AU - KEISUKE HATA AU - HIROAKI NOZAWA AU - TOSHIAKI WATANABE Y1 - 2017/09/01 UR - http://cgp.iiarjournals.org/content/14/5/341.abstract N2 - Background: Patients with ulcerative colitis (UC) are at risk of UC-associated colorectal cancer (CRC); however, little is known about genetic alterations occurring during UC carcinogenesis. We examined mutational changes in patients with colitic cancer and the features that differed between the carcinogenesis of UC and sporadic CRC. Material and Methods: Specimens were obtained from the non-neoplastic mucosa and cancer cells of 12 patients with colitic cancer. The mutational rate of oncogenes in colitic cancer was analyzed and compared to that of oncogenes in sporadic CRC. Results: We observed a lower mutation rate in adenomatous polyposis coli (APC) (16.7%(2/12) vs. 75.9%(161/212), respectively, p=0.0001) and KRAS (16.7%(2/12) vs. 42% (89/212), respectively, p=0.04) in colitic cancer than in sporadic CRC. With respect to cadherin 1 (CDH1) and fibroblast growth factor receptor 2 (FGFR2), the mutational rates for non-neoplastic colorectal mucosa were similar to those in sporadic CRC. Conclusion: We demonstrated that mutational rates for APC and KRAS differ between colitic cancer and sporadic CRC. Furthermore, we revealed that CDH1 and FGFR2 become mutated at an earlier stage in colitic carcinogenesis than in sporadic CRC. ER -