Abstract
The identification of targets which are located intracellularly in normal cells and are exposed on the surface of malignant cells is an issue in the target selection process for the development of anticancer agents. Targets with these characteristics should increase the specificity of intervention and the corresponding therapeutic window. We discuss targets such as heat-shock protein 70 (HSP70) and heat-shock protein 90 (HSP90), glucose-regulated protein 78 (GRP78), actin, cytokeratins, vimentin, nucleolin, nucleosomes, estrogen receptor-alpha variant 36 (ER-α36) and feto-acinar pancreatic protein (FAPP). Involvement of these targets in cellular processes, tumor specificity and tractability with antibody-related agents, are discussed.
- Actin
- cytokeratin(s)
- estrogen receptor
- feto-acinar pancreatic protein
- glucose-related protein 78
- heat-shock proteins 70 and 90
- Ingenuity Pathway Analysis (IPA)
- nucleolin
- nucleosomes
- tumor-specific antigens
- vimentin
- review
- Received February 10, 2011.
- Revision received February 24, 2011.
- Accepted February 24, 2011.
- Copyright© 2011 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
In this issue
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- Article
- Abstract
- Plasma Membrane-associated HSP70
- Plasma Membrane-associated HSP90
- Plasma Membrane-associated GRP78
- Plasma Membrane-associated Vimentin
- Plasma Membrane-associated Cytokeratins
- Plasma Membrane-associated Nucleolin
- hERα-36 as a Target
- Cell surface-associated FetoAcinar Pancreatic Protein (FAPP)
- Conclusion
- References
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