Figure 6.
ALCAM neighourhood analysis. Ingenuity pathway analysis (IPA) was used to create the neighborhood of genes for ALCAM. All molecules with a reported relationship to ALCAM are shown. Edges are annotated by the relationship type of two molecules: PP, Protein-protein interaction; E, expression; LO, location; PD, protein-DNA interaction; A, activation; RR, RNA-RNA interaction. All neighboring molecules of ALCAM were manually grouped and annotated according to their molecular type. MIRs, MicroRNAs; LDLR, low density lipoprotein receptor; L1CAM, L1 cell adhesion molecule; ERK1/2, mitogen-activated protein kinase 1/3; CLRN1, clarin 1; ARHGDIG, Rho GDP dissociation inhibitor (GDI) gamma; CYTH3, cytohesin 3; STK11, serine/threonine kinase 11; EGFR, epidermal growth factor receptor; MYC, myelocytomatisis viral oncogene homolog; YY1, YY1 transcription factor; EGF, epidermal growth factor; CD40L, CD40 ligand; TNF, tumor necrosis factor; CCL5, chemokine (C-C motif) ligand 5; CD6, CD6 molecule; NGFR, nerve growth factor receptor.