Cancer-related Issues of CD147

Amino acid sequence and functional motifs of human CD147. Domains and motifs are highlighted by a color code as outlined. The positions of the Ig-like domains are labeled according to Interpro Prosite PROFILE PS50835, that of the first Ig-like domain and the disulfide bridges according to Interpro SMART SM00408. All other annotations are based on the Swissprot entry BASI_HUMAN.

Amino acid sequence alignment of CD147 from different species (orthologs). Identical amino acids are indicated by a light blue background, Ig-like C2-type domains, Ig-like V-type domains and the transmembrane domains are boxed by dark blue, green and black colors, respectively. Chimp and rhesus sequences are predicted based on their genome sequences, the other sequences were derived from the Swissprot dada base (BASI_X).

Amino acid sequences of human CD147 and its paralogs Neuroplastin and Embigin. Identical amino acids are indicated by light blue color and the transmembrane domains are highlighted by a black box. The sequences are derived from the Swissprot databases: BASI_HUMAN, NPTN_HUMAN, EMB_HUMAN.

Schematic overview of CD147-associated proteins, mediators of signaling and transcriptionally induced genes. Details are given in the text. HSPG, Heparan-sulfate proteoglycan; FAK, focal adhesion kinase; MEK, Map-Erk kinase; ERK, extracellular signal-related kinases; Akt, serine-threonine kinase; MMP, matrix metalloproteinase; VEGF, vascular endothelial growth factor; α3β1 and α6β1, integrins; MCT, monocarbocylate transporter; LAT1, large neutral amino acid transporter; CD98, subunit of LAT1; ASC2, Asc-type amino acid transporter-2.

CD147 neighbourhood analysis. Ingenuity pathway analysis (IPA) was used to create the neighborhood of genes for CD147. Shown are all molecules with a direct relationship to CD147. Edges are annotated by the relationship type of two molecules: PP, protein-protein interaction; E expression; P, phosphorylation; LO, location; PD, protein DNA interaction; TR, translocation; A, activation. All neighboring molecules of CD147 were manually grouped and annotated according to their molecular type. MMP1/2/3, matrix metalloproteinases 1/2/3; NCSTN, nicastrin; Mmp, group of matrix metalloproteinases; RFXANK, regulatory factor X-associated ankyrin-containing protein; STAT4, signal transducer and activator of transcription; RYR1, ryanodine receptor 1; PTPN11, protein tyrosine phosphatase, non-receptor type 11; NT5C3, 5'-nucleotidase, cytosolic III; SLC2A4, solute carrier family 2, member 4; SLC16A4, solute carrier family 16, member 4; SLC16A1, solute carrier family 16, member 1; ATP1B2, ATPase, Na⁺/K⁺ transporting, beta 2 polypeptide; ATP1A2, ATPase, Na⁺/K⁺ transporting, alpha 2 (+) polypeptide; SCP2, sterol carrier protein 2; AJAP1, adherens junctions-associated protein 1; MCTS1, malignant T-cell amplified sequence 1; APP, amyloid beta (A4) precursor protein; RANBP3, RAN binding protein 3; ATXN10, ataxin 10; PDLIM7, PDZ and LIM domain 7; PRNP, prion protein; BAD, BCL2-associated agonist of cell death; PNN, pinin, desmosome-associated protein; BCL2L11, BCL2-like 11; PPIA/PPIC, peptidylprolyl isomerase A/C (cyclophilin A/C); LEP, leptin; CSF2, colony-stimulating factor 2; SPP1, secreted phosphoprotein 1; Pkc(s), group of protein kinases c; ERK1/2, group of ERKs; ERK, group of ERKs; Akt, group of Akts; MAP2K1/2, mitogen-activated protein kinase kinase group of kinases.