Article Figures & Data
Figures
- Figure 1.
A Bland and Altman plot of the two comparative studies testing the reproducibility of SELDI-TOF MS analysis of archival serum samples. The vast majority of peak values lay within 2 standard deviations. The concordance correlation coefficient was 1, indicating a high degree of agreement between the two studies. Less agreement was observed at higher m/z values of the test. This could be related to ex vivo proteolytic activity, limitation in SELDI-TOF MS detection at the higher mass range or different preparation and analysis sites.
- Figure 2.
A representative SELDI-TOF MS spectra comparing serum from healthy volunteers (a) and volunteers who had developed breast cancer at the time of serum collection (b). The boxed regions identify differentially expressed protein peaks 3.0, 3.4 and 8.6 kDa were overexpressed in cancer patients, and the peaks at 6.3, 8.7, 13.9 and 17.4 kDa were under expressed in cancer patients. Previously reported peaks at 8.1 and 8.9 kDa are also illustrated (X and Y axis represent mass in Daltons and peak intensity in μ amperes, respectively).
Tables
- Table I.
SELDI protein peaks in serum discriminating cancer from non-cancer groups (p<0.05).
