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Review Article

Drug Transporters as Targets for Cancer Chemotherapy

TAKEO NAKANISHI
Cancer Genomics & Proteomics May 2007, 4 (3) 241-254;
TAKEO NAKANISHI
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  • For correspondence: tnakanishi@som.umaryland.edu
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Abstract

Transporter proteins play an important role in taking up nutrients into and effluxing xenobiotics out of cells to sustain cell survival. Transporters that affect drug absorption, distribution and excretion are the so-called drug transporters. In the last decade, a number of studies revealed interactions between drug transporters and clinically important anticancer agents. Utilizing the knowledge of transporter functions offers us the possibility of delivering a drug to the target tissues, avoiding distribution to other tissues and improving oral bioavailability. Many transporters have been reported to be differentially up-regulated in cancer cells compared to normal tissues, suggesting that the differential expression of transporters in cancer cells may provide good targets for enhancing drug delivery as well as diagnostic markers for cancer therapy. This review will focus on the role of drug transporters in the adaptation and growth of tumors and in their potential usefulness as therapeutic targets in cancer.

Keywords:
  • SLC transporters
  • ABC transporters
  • cancer therapy
  • multidrug resistance
  • review

Footnotes

  • Abbreviations: SLC: solute carrier; ABC: ATP-binding cassette; PEPT: the H+/peptide co-transporter; PDH: photodynamic therapy; NOS: nitric oxide synthase; CNS: central nervous system; OATP: organic anion transporting polypeptide; CNT: concentrative nucleoside transporter; ENT: equilibrative nucleoside transporter; NBMPR: nitrobenzylthioinosine; 5FU: fluorouracil; BBB: blood-brain barrier; MDR: multidrug resistance.

    • Received March 27, 2007.
    • Revision received April 27, 2007.
    • Accepted May 2, 2007.
  • Copyright© 2007 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved
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Cancer Genomics - Proteomics: 4 (3)
Cancer Genomics & Proteomics
Vol. 4, Issue 3
May-June 2007
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Drug Transporters as Targets for Cancer Chemotherapy
TAKEO NAKANISHI
Cancer Genomics & Proteomics May 2007, 4 (3) 241-254;

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Drug Transporters as Targets for Cancer Chemotherapy
TAKEO NAKANISHI
Cancer Genomics & Proteomics May 2007, 4 (3) 241-254;
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