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Research ArticleExperimental Studies
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A Multi-omics PTM Atlas Reveals Key Insights into Metabolic Reprogramming in Colorectal Cancer

TIANYUAN LI, JINGJING DONG, YUJIE ZHANG, ERJIAO HAO, JIE DU, MIN FENG, FENG ZHU, JUAN QIN, WEI ZHANG and YONG DAI
Cancer Genomics & Proteomics May 2026, 23 (3) 448-469; DOI: https://doi.org/10.21873/cgp.20584
TIANYUAN LI
1School of Medicine, Anhui University of Science & Technology, Huainan, P.R. China;
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JINGJING DONG
2Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, P.R. China;
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YUJIE ZHANG
1School of Medicine, Anhui University of Science & Technology, Huainan, P.R. China;
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ERJIAO HAO
1School of Medicine, Anhui University of Science & Technology, Huainan, P.R. China;
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JIE DU
1School of Medicine, Anhui University of Science & Technology, Huainan, P.R. China;
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MIN FENG
1School of Medicine, Anhui University of Science & Technology, Huainan, P.R. China;
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FENG ZHU
3The First Hospital of Anhui University of Science and Technology, Huainan, P.R. China;
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JUAN QIN
4Department of Reproductive Medicine Center, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, Shenzhen, P.R. China;
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WEI ZHANG
5Department of Clinical Laboratory, Peking University Shenzhen Hospital, Shenzhen, P.R. China;
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  • For correspondence: w-z12{at}tsinghua.org.cn daiyong22{at}aust.edu.cn
YONG DAI
1School of Medicine, Anhui University of Science & Technology, Huainan, P.R. China;
3The First Hospital of Anhui University of Science and Technology, Huainan, P.R. China;
6Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Huainan, P.R. China;
7Anhui Provincial Academician Workstation of Anhui University of Science & Technology for Autoimmune Disease Diagnostic Technology, Huainan, P.R. China
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  • For correspondence: w-z12{at}tsinghua.org.cn daiyong22{at}aust.edu.cn
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Article Information

vol. 23 no. 3 448-469
DOI 
https://doi.org/10.21873/cgp.20584
PMID 
42055631

Published By 
International Institute of Anticancer Research
Print ISSN 
1109-6535
Online ISSN 
1790-6245
History 
  • Received January 11, 2026
  • Revision received February 13, 2026
  • Accepted March 18, 2026
  • Published online April 29, 2026.

Copyright & License 
Copyright © 2026 The Author(s). Published by the International Institute of Anticancer Research. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0).

Author Information

  1. TIANYUAN LI1,*,
  2. JINGJING DONG2,*,
  3. YUJIE ZHANG1,
  4. ERJIAO HAO1,
  5. JIE DU1,
  6. MIN FENG1,
  7. FENG ZHU3,
  8. JUAN QIN4,
  9. WEI ZHANG5⇑ and
  10. YONG DAI1,3,6,7⇑
  1. 1School of Medicine, Anhui University of Science & Technology, Huainan, P.R. China;
  2. 2Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, P.R. China;
  3. 3The First Hospital of Anhui University of Science and Technology, Huainan, P.R. China;
  4. 4Department of Reproductive Medicine Center, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, Shenzhen, P.R. China;
  5. 5Department of Clinical Laboratory, Peking University Shenzhen Hospital, Shenzhen, P.R. China;
  6. 6Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Huainan, P.R. China;
  7. 7Anhui Provincial Academician Workstation of Anhui University of Science & Technology for Autoimmune Disease Diagnostic Technology, Huainan, P.R. China
  1. Wei Zhang, Department of Clinical Laboratory, Peking University Shenzhen Hospital, Shenzhen, P.R. China. Tel: +86 18026938895, e-mail: w-z12{at}tsinghua.org.cn and Yong Dai, School of Medicine, Anhui University of Science & Technology, Huainan, P.R. China. Tel: +86 13802201510, e-mail: daiyong22{at}aust.edu.cn
  1. ↵* These Authors contributed equally to this work.

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Cancer Genomics - Proteomics: 23 (3)
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A Multi-omics PTM Atlas Reveals Key Insights into Metabolic Reprogramming in Colorectal Cancer
TIANYUAN LI, JINGJING DONG, YUJIE ZHANG, ERJIAO HAO, JIE DU, MIN FENG, FENG ZHU, JUAN QIN, WEI ZHANG, YONG DAI
Cancer Genomics & Proteomics May 2026, 23 (3) 448-469; DOI: 10.21873/cgp.20584

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A Multi-omics PTM Atlas Reveals Key Insights into Metabolic Reprogramming in Colorectal Cancer
TIANYUAN LI, JINGJING DONG, YUJIE ZHANG, ERJIAO HAO, JIE DU, MIN FENG, FENG ZHU, JUAN QIN, WEI ZHANG, YONG DAI
Cancer Genomics & Proteomics May 2026, 23 (3) 448-469; DOI: 10.21873/cgp.20584
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Keywords

  • Colorectal cancer
  • phosphorylation
  • ubiquitination
  • malonylation
  • metabolism
  • PTM
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