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CD84 as a Prognostic Biomarker and Therapeutic Target in Breast Cancer: Interconnections With PDL1, CD74, and Immune Tolerance Mechanisms

UMAR WAZIR, AMBER X. LI, CAROLYN CAI WANG, HENSON HAN GAO, TRACEY A. MARTIN, WEN G. JIANG and KEFAH MOKBEL
Cancer Genomics & Proteomics July 2025, 22 (4) 557-563; DOI: https://doi.org/10.21873/cgp.20521
UMAR WAZIR
1The London Breast Institute, Princess Grace Hospital, London, U.K.;
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AMBER X. LI
2Metastasis Research Group, University of Wales College of Medicine, Cardiff, U.K.
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CAROLYN CAI WANG
2Metastasis Research Group, University of Wales College of Medicine, Cardiff, U.K.
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HENSON HAN GAO
2Metastasis Research Group, University of Wales College of Medicine, Cardiff, U.K.
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TRACEY A. MARTIN
2Metastasis Research Group, University of Wales College of Medicine, Cardiff, U.K.
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WEN G. JIANG
2Metastasis Research Group, University of Wales College of Medicine, Cardiff, U.K.
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KEFAH MOKBEL
1The London Breast Institute, Princess Grace Hospital, London, U.K.;
2Metastasis Research Group, University of Wales College of Medicine, Cardiff, U.K.
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  • For correspondence: Kefah.Mokbel{at}hcahealthcare.co.uk
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    Figure 1.

    Association between CD84 expression and overall survival in breast cancer. Kaplan–Meier survival curve comparing overall survival (OS) between patients with high versus low CD84 mRNA expression levels. High CD84 expression is associated with significantly lower overall survival (p=0.034).

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    Figure 2.

    Prognostic value of the CD84/CD48/VAV1/CTNNB1 combined signature in breast cancer. A) Kaplan–Meier survival analysis showing overall survival (OS) in patients with high vs. low expression of the combined CD84/CD48/VAV1/CTNNB1 signature (p=0.000025). B) Kaplan–Meier survival analysis showing recurrence-free survival (RFS) in patients with high vs. low expression of the same combined signature (p=0.000077).

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Cancer Genomics - Proteomics: 22 (4)
Cancer Genomics & Proteomics
Vol. 22, Issue 4
July-August 2025
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CD84 as a Prognostic Biomarker and Therapeutic Target in Breast Cancer: Interconnections With PDL1, CD74, and Immune Tolerance Mechanisms
UMAR WAZIR, AMBER X. LI, CAROLYN CAI WANG, HENSON HAN GAO, TRACEY A. MARTIN, WEN G. JIANG, KEFAH MOKBEL
Cancer Genomics & Proteomics Jul 2025, 22 (4) 557-563; DOI: 10.21873/cgp.20521

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CD84 as a Prognostic Biomarker and Therapeutic Target in Breast Cancer: Interconnections With PDL1, CD74, and Immune Tolerance Mechanisms
UMAR WAZIR, AMBER X. LI, CAROLYN CAI WANG, HENSON HAN GAO, TRACEY A. MARTIN, WEN G. JIANG, KEFAH MOKBEL
Cancer Genomics & Proteomics Jul 2025, 22 (4) 557-563; DOI: 10.21873/cgp.20521
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Keywords

  • CD84
  • CD74
  • VAV1
  • CTNNB1
  • CD48
  • PD-L1
  • Breast cancer
  • immune tolerance
  • checkpoint inhibitors
  • TNBC
  • immunotherapy
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