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Open Access

CD84 as a Prognostic Biomarker and Therapeutic Target in Breast Cancer: Interconnections With PDL1, CD74, and Immune Tolerance Mechanisms

UMAR WAZIR, AMBER X. LI, CAROLYN CAI WANG, HENSON HAN GAO, TRACEY A. MARTIN, WEN G. JIANG and KEFAH MOKBEL
Cancer Genomics & Proteomics July 2025, 22 (4) 557-563; DOI: https://doi.org/10.21873/cgp.20521
UMAR WAZIR
1The London Breast Institute, Princess Grace Hospital, London, U.K.;
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AMBER X. LI
2Metastasis Research Group, University of Wales College of Medicine, Cardiff, U.K.
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CAROLYN CAI WANG
2Metastasis Research Group, University of Wales College of Medicine, Cardiff, U.K.
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HENSON HAN GAO
2Metastasis Research Group, University of Wales College of Medicine, Cardiff, U.K.
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TRACEY A. MARTIN
2Metastasis Research Group, University of Wales College of Medicine, Cardiff, U.K.
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WEN G. JIANG
2Metastasis Research Group, University of Wales College of Medicine, Cardiff, U.K.
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KEFAH MOKBEL
1The London Breast Institute, Princess Grace Hospital, London, U.K.;
2Metastasis Research Group, University of Wales College of Medicine, Cardiff, U.K.
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  • For correspondence: Kefah.Mokbel{at}hcahealthcare.co.uk
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Article Information

vol. 22 no. 4 557-563
DOI 
https://doi.org/10.21873/cgp.20521
PMID 
40571312

Published By 
International Institute of Anticancer Research
Print ISSN 
1109-6535
Online ISSN 
1790-6245
History 
  • Received April 20, 2025
  • Revision received May 5, 2025
  • Accepted May 7, 2025
  • Published online June 26, 2025.

Copyright & License 
Copyright © 2025 The Author(s). Published by the International Institute of Anticancer Research. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0).

Author Information

  1. UMAR WAZIR1,
  2. AMBER X. LI2,
  3. CAROLYN CAI WANG2,
  4. HENSON HAN GAO2,
  5. TRACEY A. MARTIN2,
  6. WEN G. JIANG2 and
  7. KEFAH MOKBEL1,2⇑
  1. 1The London Breast Institute, Princess Grace Hospital, London, U.K.;
  2. 2Metastasis Research Group, University of Wales College of Medicine, Cardiff, U.K.
  1. Prof. Kefah Mokbel, The London Breast Institute, The Princess Grace Hospital, 42-52 Nottingham Place, London W1U 5NY, U.K. E-mail: Kefah.Mokbel{at}hcahealthcare.co.uk
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Cancer Genomics - Proteomics: 22 (4)
Cancer Genomics & Proteomics
Vol. 22, Issue 4
July-August 2025
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CD84 as a Prognostic Biomarker and Therapeutic Target in Breast Cancer: Interconnections With PDL1, CD74, and Immune Tolerance Mechanisms
UMAR WAZIR, AMBER X. LI, CAROLYN CAI WANG, HENSON HAN GAO, TRACEY A. MARTIN, WEN G. JIANG, KEFAH MOKBEL
Cancer Genomics & Proteomics Jul 2025, 22 (4) 557-563; DOI: 10.21873/cgp.20521

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CD84 as a Prognostic Biomarker and Therapeutic Target in Breast Cancer: Interconnections With PDL1, CD74, and Immune Tolerance Mechanisms
UMAR WAZIR, AMBER X. LI, CAROLYN CAI WANG, HENSON HAN GAO, TRACEY A. MARTIN, WEN G. JIANG, KEFAH MOKBEL
Cancer Genomics & Proteomics Jul 2025, 22 (4) 557-563; DOI: 10.21873/cgp.20521
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Keywords

  • CD84
  • CD74
  • VAV1
  • CTNNB1
  • CD48
  • PD-L1
  • Breast cancer
  • immune tolerance
  • checkpoint inhibitors
  • TNBC
  • immunotherapy
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