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Open Access

C1orf50 Drives Malignant Melanoma Progression Through the Regulation of Stemness

YUSUKE OTANI, MASAKI MAEKAWA, ATSUSHI TANAKA, TIRSO PEÑA, VANESSA D. CHIN, ANNA ROGACHEVSKAYA, SHINICHI TOYOOKA, MICHAEL H. ROEHRL and ATSUSHI FUJIMURA
Cancer Genomics & Proteomics July 2025, 22 (4) 510-524; DOI: https://doi.org/10.21873/cgp.20518
YUSUKE OTANI
1Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, U.S.A.;
2Harvard Medical School, Boston, MA, U.S.A.;
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MASAKI MAEKAWA
1Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, U.S.A.;
2Harvard Medical School, Boston, MA, U.S.A.;
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ATSUSHI TANAKA
1Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, U.S.A.;
2Harvard Medical School, Boston, MA, U.S.A.;
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TIRSO PEÑA
1Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, U.S.A.;
2Harvard Medical School, Boston, MA, U.S.A.;
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VANESSA D. CHIN
3UMass Chan Medical School, UMass Memorial Medical Center, Worcester, MA, U.S.A.;
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ANNA ROGACHEVSKAYA
1Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, U.S.A.;
2Harvard Medical School, Boston, MA, U.S.A.;
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SHINICHI TOYOOKA
4Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;
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MICHAEL H. ROEHRL
1Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, U.S.A.;
2Harvard Medical School, Boston, MA, U.S.A.;
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ATSUSHI FUJIMURA
5Department of Molecular Physiology, Kagawa University Faculty of Medicine, Graduate School of Medicine, Kagawa, Japan;
6Department of Cellular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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  • For correspondence: fujimura.atsushi{at}kagawa-u.ac.jp
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Article Information

vol. 22 no. 4 510-524
DOI 
https://doi.org/10.21873/cgp.20518
PMID 
40571314

Published By 
International Institute of Anticancer Research
Print ISSN 
1109-6535
Online ISSN 
1790-6245
History 
  • Received April 24, 2025
  • Revision received May 2, 2025
  • Accepted May 5, 2025
  • Published online June 26, 2025.

Copyright & License 
Copyright © 2025 The Author(s). Published by the International Institute of Anticancer Research. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0).

Author Information

  1. YUSUKE OTANI1,2,*,
  2. MASAKI MAEKAWA1,2,*,
  3. ATSUSHI TANAKA1,2,*,
  4. TIRSO PEÑA1,2,
  5. VANESSA D. CHIN3,
  6. ANNA ROGACHEVSKAYA1,2,
  7. SHINICHI TOYOOKA4,
  8. MICHAEL H. ROEHRL1,2 and
  9. ATSUSHI FUJIMURA5,6⇑
  1. 1Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, U.S.A.;
  2. 2Harvard Medical School, Boston, MA, U.S.A.;
  3. 3UMass Chan Medical School, UMass Memorial Medical Center, Worcester, MA, U.S.A.;
  4. 4Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;
  5. 5Department of Molecular Physiology, Kagawa University Faculty of Medicine, Graduate School of Medicine, Kagawa, Japan;
  6. 6Department of Cellular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
  1. Atsushi Fujimura, MD, Ph.D., Department of Molecular Physiology, Kagawa University Faculty of Medicine, Graduate School of Medicine, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan. Tel: +81 878912095, e-mail: fujimura.atsushi{at}kagawa-u.ac.jp
  1. ↵* These Authors equally contributed to this work.

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Cancer Genomics - Proteomics: 22 (4)
Cancer Genomics & Proteomics
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C1orf50 Drives Malignant Melanoma Progression Through the Regulation of Stemness
YUSUKE OTANI, MASAKI MAEKAWA, ATSUSHI TANAKA, TIRSO PEÑA, VANESSA D. CHIN, ANNA ROGACHEVSKAYA, SHINICHI TOYOOKA, MICHAEL H. ROEHRL, ATSUSHI FUJIMURA
Cancer Genomics & Proteomics Jul 2025, 22 (4) 510-524; DOI: 10.21873/cgp.20518

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C1orf50 Drives Malignant Melanoma Progression Through the Regulation of Stemness
YUSUKE OTANI, MASAKI MAEKAWA, ATSUSHI TANAKA, TIRSO PEÑA, VANESSA D. CHIN, ANNA ROGACHEVSKAYA, SHINICHI TOYOOKA, MICHAEL H. ROEHRL, ATSUSHI FUJIMURA
Cancer Genomics & Proteomics Jul 2025, 22 (4) 510-524; DOI: 10.21873/cgp.20518
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Keywords

  • C1orf50
  • melanoma
  • cancer stem cells
  • YAP/TAZ
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