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Extensive DNA Damage and Loss of Cell Viability Occur Synergistically With the Combination of Recombinant Methioninase and Paclitaxel on Pancreatic Cancer Cells which Report DNA-Damage Response in Real Time

SEI MORINAGA, QINGHONG HAN, KOHEI MIZUTA, BYUNG MO KANG, MOTOKAZU SATO, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN
Cancer Genomics & Proteomics November 2024, 21 (6) 585-590; DOI: https://doi.org/10.21873/cgp.20475

Article Information

vol. 21 no. 6 585-590
DOI 
https://doi.org/10.21873/cgp.20475
PMID 
39467627
Published By 
International Institute of Anticancer Research
Print ISSN 
1109-6535
Online ISSN 
1790-6245
History 
  • Received July 14, 2024
  • Revision received August 10, 2024
  • Accepted August 17, 2024
  • Published online October 28, 2024.
Copyright & License 
Copyright © 2024 The Author(s). Published by the International Institute of Anticancer Research. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0).

Author Information

  1. SEI MORINAGA1,2,3,
  2. QINGHONG HAN1,
  3. KOHEI MIZUTA1,2,
  4. BYUNG MO KANG1,2,
  5. MOTOKAZU SATO1,2,
  6. MICHAEL BOUVET2,
  7. NORIO YAMAMOTO3,
  8. KATSUHIRO HAYASHI3,
  9. HIROAKI KIMURA3,
  10. SHINJI MIWA3,
  11. KENTARO IGARASHI3,
  12. TAKASHI HIGUCHI3,
  13. HIROYUKI TSUCHIYA3,
  14. SATORU DEMURA3 and
  15. ROBERT M. HOFFMAN1,2⇑
  1. 1AntiCancer Inc., San Diego, CA, U.S.A.
  2. 2Department of Surgery, University of California, San Diego, CA, U.S.A.
  3. 3Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan
  1. Correspondence to: Robert M. Hoffman, AntiCancer Inc, 7917 Ostrow St, Suite B, San Diego, CA, 92111, U.S.A. Tel: +1 6198852284, e-mail: all{at}anticancer.com
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Extensive DNA Damage and Loss of Cell Viability Occur Synergistically With the Combination of Recombinant Methioninase and Paclitaxel on Pancreatic Cancer Cells which Report DNA-Damage Response in Real Time
SEI MORINAGA, QINGHONG HAN, KOHEI MIZUTA, BYUNG MO KANG, MOTOKAZU SATO, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, HIROYUKI TSUCHIYA, SATORU DEMURA, ROBERT M. HOFFMAN
Cancer Genomics & Proteomics Nov 2024, 21 (6) 585-590; DOI: 10.21873/cgp.20475
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