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Association of Androgen Receptor and PD-L1 Expression in Upper Urinary Tract Urothelial Carcinoma

YOHEI OKUDA, TAIGO KATO, KAZUTOSHI FUJITA, HIROAKI FUSHIMI, HIROSHI MIYAMOTO, GEORGE J. NETTO and NORIO NONOMURA
Cancer Genomics & Proteomics March 2024, 21 (2) 137-143; DOI: https://doi.org/10.21873/cgp.20435
YOHEI OKUDA
1Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan;
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TAIGO KATO
1Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan;
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  • For correspondence: kato{at}uro.med.oaska-u.ac.jp
KAZUTOSHI FUJITA
2Department of Urology, Kindai University Faculty of Medicine, Sayama, Japan;
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HIROAKI FUSHIMI
3Department of Pathology, Osaka General Medical Center, Osaka, Japan;
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HIROSHI MIYAMOTO
4Departments of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, U.S.A.;
5Urology, University of Rochester Medical Center, Rochester, NY, U.S.A.;
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GEORGE J. NETTO
6Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, U.S.A.
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NORIO NONOMURA
1Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan;
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    Figure 1.

    PD-L1 expression by sex, affected side, tumor grade, and age. There was no significant difference of PD-L1 positivity between (A) male and female, (B) renal pelvis and ureter, (C) low and high grade, and (D) age <70 and ≥70.

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    Figure 2.

    The positive incidence of androgen receptor expression by affected side renal pelvis or ureter and sex. (A) The positive incidence of androgen receptor (AR) expression in ureteral cancer cells was significantly higher than that in renal pelvis cancer cells (p=0.0445). (B) The positive incidence of AR expression on cancer cells in males tended to be higher than that in females (p=0.0715). Fisher’s exact test was performed to evaluate the association between localization of the primary tumor and the expression status of AR. AR: Androgen receptor.

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    Figure 3.

    Correlation of the expression level of androgen receptor and PD-L1 in upper urinary tract urothelial carcinoma. Androgen receptor (AR)-negative patients had significantly higher PD-L1 expression levels (mean value; 4.70%) compared with AR-positive group (mean value; 2.55%) (p=0.0324). AR: Androgen receptor.

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    Figure 4.

    Kaplan-Meier curves for cancer-specific survival stratified by the status of androgen receptor and PD-L1 expression. Among patients with androgen receptor (AR)+ tumors, negative PD-L1 expression was significantly associated with shorter cancer specific survival compared to those with positive PD-L1 expression (p=0.0493). On the other hand, PD-L1 expression in patients with AR-tumors had no significant prognostic impact (p=0.920). Differences between the two groups were assessed using the log-rank test. AR: Androgen receptor.

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Cancer Genomics - Proteomics: 21 (2)
Cancer Genomics & Proteomics
Vol. 21, Issue 2
March-April 2024
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Association of Androgen Receptor and PD-L1 Expression in Upper Urinary Tract Urothelial Carcinoma
YOHEI OKUDA, TAIGO KATO, KAZUTOSHI FUJITA, HIROAKI FUSHIMI, HIROSHI MIYAMOTO, GEORGE J. NETTO, NORIO NONOMURA
Cancer Genomics & Proteomics Mar 2024, 21 (2) 137-143; DOI: 10.21873/cgp.20435

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Association of Androgen Receptor and PD-L1 Expression in Upper Urinary Tract Urothelial Carcinoma
YOHEI OKUDA, TAIGO KATO, KAZUTOSHI FUJITA, HIROAKI FUSHIMI, HIROSHI MIYAMOTO, GEORGE J. NETTO, NORIO NONOMURA
Cancer Genomics & Proteomics Mar 2024, 21 (2) 137-143; DOI: 10.21873/cgp.20435
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Keywords

  • Androgen receptor
  • AR
  • programmed cell death ligand 1
  • PD-L1
  • upper urinary tract urothelial carcinoma
  • UTUC
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