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Metastatic Lymph Node 64 (MLN64) Expression in Gastric Cancer: The Clinical and Molecular Implications in Drug Resistance

AMBER XINYU LI, JIMMY JIANYUAN ZENG, ELYAS KHAN, Q. PING DOU, XINGUO ZHUANG, EDISON KE JI, FIONA RUGE, TRACEY A. MARTIN, SHUQIN JIA and WEN G. JIANG
Cancer Genomics & Proteomics January 2024, 21 (1) 30-40; DOI: https://doi.org/10.21873/cgp.20427
AMBER XINYU LI
1Cardiff University School of Medicine, Cardiff, U.K.;
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JIMMY JIANYUAN ZENG
1Cardiff University School of Medicine, Cardiff, U.K.;
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ELYAS KHAN
2Karmanos Cancer Institute, Department of Oncology, School of Medicine, Wayne State University, Detroit, MI, U.S.A.;
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Q. PING DOU
1Cardiff University School of Medicine, Cardiff, U.K.;
2Karmanos Cancer Institute, Department of Oncology, School of Medicine, Wayne State University, Detroit, MI, U.S.A.;
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XINGUO ZHUANG
1Cardiff University School of Medicine, Cardiff, U.K.;
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EDISON KE JI
3Gastrointestinal Cancer Centre, Peking University Cancer Hospital, Beijing, P.R. China
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FIONA RUGE
1Cardiff University School of Medicine, Cardiff, U.K.;
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TRACEY A. MARTIN
1Cardiff University School of Medicine, Cardiff, U.K.;
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SHUQIN JIA
3Gastrointestinal Cancer Centre, Peking University Cancer Hospital, Beijing, P.R. China
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WEN G. JIANG
1Cardiff University School of Medicine, Cardiff, U.K.;
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  • For correspondence: jiangw{at}cardiff.ac.uk
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    Figure 1.

    Overall survival (OS) and disease-free survival (DFS) curves of patients with gastric cancer with nodal positive status (A, B).

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    Figure 2.

    The implications of NRG4 alone and in combination with ERBB4 in the overall survival (OS) of patients with gastric cancer are illustrated in A and B. Patients with integrated expression of MLN64/NRG4/ERBB4 had a significantly shortened OS (C).

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    Figure 3.

    Survival curves of patients in subgroups of cohort B. A) Overall survival (OS) curve of patients who received neoadjuvant chemotherapy (NAC). Patients were subclassified into MLN64 high and low groups, B) based on patients’ chemo-response, C) MLN64 expression within the NAC responsive group, D) integrated expression of MLN64/NRG4/ERBB4.

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    Figure 4.

    ECIS-based assessment of cell adhesion and migration at 4,000 Hz for both HGC27 (A, B) and AGS (C, D) cell models.

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    Figure 5.

    ECIS-based assessment of cell adhesion at 4,000 Hz for AGS (C, D) cell models under different treatments.

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Cancer Genomics - Proteomics: 21 (1)
Cancer Genomics & Proteomics
Vol. 21, Issue 1
January-February 2024
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Metastatic Lymph Node 64 (MLN64) Expression in Gastric Cancer: The Clinical and Molecular Implications in Drug Resistance
AMBER XINYU LI, JIMMY JIANYUAN ZENG, ELYAS KHAN, Q. PING DOU, XINGUO ZHUANG, EDISON KE JI, FIONA RUGE, TRACEY A. MARTIN, SHUQIN JIA, WEN G. JIANG
Cancer Genomics & Proteomics Jan 2024, 21 (1) 30-40; DOI: 10.21873/cgp.20427

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Metastatic Lymph Node 64 (MLN64) Expression in Gastric Cancer: The Clinical and Molecular Implications in Drug Resistance
AMBER XINYU LI, JIMMY JIANYUAN ZENG, ELYAS KHAN, Q. PING DOU, XINGUO ZHUANG, EDISON KE JI, FIONA RUGE, TRACEY A. MARTIN, SHUQIN JIA, WEN G. JIANG
Cancer Genomics & Proteomics Jan 2024, 21 (1) 30-40; DOI: 10.21873/cgp.20427
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Keywords

  • MLN64
  • STARD3
  • Gastric cancer
  • ERBB4
  • prognosis
  • NRG
  • signalling
  • drug response
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