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A Multiplex Biomarker Assay Improves the Prediction of Survival in Epithelial Ovarian Cancer

ARTURAS DOBILAS, ANNA ÅKESSON, PIA LEANDERSSON and CHRISTER BORGFELDT
Cancer Genomics & Proteomics May 2023, 20 (3) 273-280; DOI: https://doi.org/10.21873/cgp.20380
ARTURAS DOBILAS
1Department of Obstetrics and Gynecology, Skåne University Hospital, Lund, Sweden;
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  • For correspondence: arturas.dobilas@med.lu.se
ANNA ÅKESSON
2Clinical Studies Sweden–Forum South, Skåne University Hospital, Lund, Sweden;
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PIA LEANDERSSON
3Department of Reproductive Medicine Center, Skåne University Hospital, Malmo, Sweden
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CHRISTER BORGFELDT
1Department of Obstetrics and Gynecology, Skåne University Hospital, Lund, Sweden;
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    Figure 1.

    Comparison of the reference model and models with added biomarkers. A three-biomarker model including NT-3, GPNMB, and MSLN with age as the reference model showed the highest prediction of survival (AUC=0.792, p=0.004).

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    Figure 2.

    Comparison of the reference model and models with added biomarkers. A three-biomarker model including NT-3+GPNMB+MSLN with age+CA-125+HE4 as the reference model showed the highest prediction of survival (AUC=0.825, p=0.003).

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    Figure 3.

    Comparison of the reference model and models with added biomarkers. A three-biomarker model including CCL28+TCL1A+GPNMB with Stage I+II vs. III+IV+age as the reference model showed the highest prediction of survival (AUC=0.899, p=0.048).

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    Figure 4.

    Comparison of the reference model and models with added biomarkers. The model including stage I+II vs. III+CCL28+GPNMB1 with age as the reference model showed the highest prediction of survival (AUC=0.864, p<0.001).

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    Figure 5.

    Kaplan-Meier analysis of overall survival in patients in terms of CA125 and HE4 levels. Patients with both values above the median are shown in red, and patients with one or both biomarkers below the median are shown in blue.

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Cancer Genomics - Proteomics: 20 (3)
Cancer Genomics & Proteomics
Vol. 20, Issue 3
May-June 2023
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A Multiplex Biomarker Assay Improves the Prediction of Survival in Epithelial Ovarian Cancer
ARTURAS DOBILAS, ANNA ÅKESSON, PIA LEANDERSSON, CHRISTER BORGFELDT
Cancer Genomics & Proteomics May 2023, 20 (3) 273-280; DOI: 10.21873/cgp.20380

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A Multiplex Biomarker Assay Improves the Prediction of Survival in Epithelial Ovarian Cancer
ARTURAS DOBILAS, ANNA ÅKESSON, PIA LEANDERSSON, CHRISTER BORGFELDT
Cancer Genomics & Proteomics May 2023, 20 (3) 273-280; DOI: 10.21873/cgp.20380
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Keywords

  • Epithelial ovarian cancer
  • overall survival
  • biomarker
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