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Research ArticleArticle
Open Access

Small RNA Sequencing Identifies a Six-MicroRNA Signature Enabling Classification of Brain Metastases According to their Origin

IVANA ROSKOVA, MAREK VECERA, LENKA RADOVA, KAROLINA TRACHTOVA, FRANTISEK SIEGL, MARKETA HERMANOVA, MICHAL HENDRYCH, LEOS KREN, VACLAV VYBIHAL, HANA VALEKOVA, PETRA KASPAROVA, IVANA KOLOUSKOVA, TOMAS KAZDA, ONDREJ SLABY, RADIM JANCALEK, JIRI SANA and MARTIN SMRCKA
Cancer Genomics & Proteomics January 2023, 20 (1) 18-29; DOI: https://doi.org/10.21873/cgp.20361
IVANA ROSKOVA
1Department of Neurosurgery, University Hospital Brno, Brno, Czech Republic;
2Faculty of Medicine, Masaryk University, Brno, Czech Republic;
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MAREK VECERA
3Central European Institute of Technology, Masaryk University, Brno, Czech Republic;
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LENKA RADOVA
3Central European Institute of Technology, Masaryk University, Brno, Czech Republic;
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KAROLINA TRACHTOVA
3Central European Institute of Technology, Masaryk University, Brno, Czech Republic;
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FRANTISEK SIEGL
3Central European Institute of Technology, Masaryk University, Brno, Czech Republic;
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MARKETA HERMANOVA
2Faculty of Medicine, Masaryk University, Brno, Czech Republic;
4First Department of Pathology, St. Anne’s University Hospital, Brno, Czech Republic;
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MICHAL HENDRYCH
2Faculty of Medicine, Masaryk University, Brno, Czech Republic;
4First Department of Pathology, St. Anne’s University Hospital, Brno, Czech Republic;
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LEOS KREN
5Department of Pathology, University Hospital Brno, Brno, Czech Republic;
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VACLAV VYBIHAL
1Department of Neurosurgery, University Hospital Brno, Brno, Czech Republic;
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HANA VALEKOVA
2Faculty of Medicine, Masaryk University, Brno, Czech Republic;
6Department of Neurosurgery, St. Anne’s University Hospital, Brno, Czech Republic;
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PETRA KASPAROVA
7The Fingerland Department of Pathology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic;
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IVANA KOLOUSKOVA
2Faculty of Medicine, Masaryk University, Brno, Czech Republic;
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TOMAS KAZDA
2Faculty of Medicine, Masaryk University, Brno, Czech Republic;
8Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic;
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ONDREJ SLABY
3Central European Institute of Technology, Masaryk University, Brno, Czech Republic;
9Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic;
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RADIM JANCALEK
2Faculty of Medicine, Masaryk University, Brno, Czech Republic;
6Department of Neurosurgery, St. Anne’s University Hospital, Brno, Czech Republic;
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JIRI SANA
3Central European Institute of Technology, Masaryk University, Brno, Czech Republic;
10Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
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  • For correspondence: sana.jiri{at}gmail.com
MARTIN SMRCKA
1Department of Neurosurgery, University Hospital Brno, Brno, Czech Republic;
2Faculty of Medicine, Masaryk University, Brno, Czech Republic;
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  • For correspondence: smrcka.martin{at}fnbrno.cz
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Article Information

vol. 20 no. 1 18-29
DOI 
https://doi.org/10.21873/cgp.20361
PMID 
36581345

Published By 
International Institute of Anticancer Research
Print ISSN 
1109-6535
Online ISSN 
1790-6245
History 
  • Received November 6, 2022
  • Revision received November 19, 2022
  • Accepted November 22, 2022
  • Published online December 29, 2022.

Copyright & License 
Copyright © 2023 The Author(s). Published by the International Institute of Anticancer Research. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0).

Author Information

  1. IVANA ROSKOVA1,2,
  2. MAREK VECERA3,
  3. LENKA RADOVA3,
  4. KAROLINA TRACHTOVA3,
  5. FRANTISEK SIEGL3,
  6. MARKETA HERMANOVA2,4,
  7. MICHAL HENDRYCH2,4,
  8. LEOS KREN5,
  9. VACLAV VYBIHAL1,
  10. HANA VALEKOVA2,6,
  11. PETRA KASPAROVA7,
  12. IVANA KOLOUSKOVA2,
  13. TOMAS KAZDA2,8,
  14. ONDREJ SLABY3,9,
  15. RADIM JANCALEK2,6,
  16. JIRI SANA3,10⇑ and
  17. MARTIN SMRCKA1,2⇑
  1. 1Department of Neurosurgery, University Hospital Brno, Brno, Czech Republic;
  2. 2Faculty of Medicine, Masaryk University, Brno, Czech Republic;
  3. 3Central European Institute of Technology, Masaryk University, Brno, Czech Republic;
  4. 4First Department of Pathology, St. Anne’s University Hospital, Brno, Czech Republic;
  5. 5Department of Pathology, University Hospital Brno, Brno, Czech Republic;
  6. 6Department of Neurosurgery, St. Anne’s University Hospital, Brno, Czech Republic;
  7. 7The Fingerland Department of Pathology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic;
  8. 8Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic;
  9. 9Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic;
  10. 10Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
  1. Correspondence to: Jiri Sana, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic. Tel: +42 0549495246, e-mail: sana.jiri{at}gmail.com
  2. Correspondence to: Martin Smrcka, Department of Neurosurgery, University Hospital Brno, Jihlavska 20, 625 00 Brno, Czech Republic, Tel: +42 0532232884, e-mail: smrcka.martin{at}fnbrno.cz
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Cancer Genomics - Proteomics: 20 (1)
Cancer Genomics & Proteomics
Vol. 20, Issue 1
January-February 2023
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Small RNA Sequencing Identifies a Six-MicroRNA Signature Enabling Classification of Brain Metastases According to their Origin
IVANA ROSKOVA, MAREK VECERA, LENKA RADOVA, KAROLINA TRACHTOVA, FRANTISEK SIEGL, MARKETA HERMANOVA, MICHAL HENDRYCH, LEOS KREN, VACLAV VYBIHAL, HANA VALEKOVA, PETRA KASPAROVA, IVANA KOLOUSKOVA, TOMAS KAZDA, ONDREJ SLABY, RADIM JANCALEK, JIRI SANA, MARTIN SMRCKA
Cancer Genomics & Proteomics Jan 2023, 20 (1) 18-29; DOI: 10.21873/cgp.20361

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Small RNA Sequencing Identifies a Six-MicroRNA Signature Enabling Classification of Brain Metastases According to their Origin
IVANA ROSKOVA, MAREK VECERA, LENKA RADOVA, KAROLINA TRACHTOVA, FRANTISEK SIEGL, MARKETA HERMANOVA, MICHAL HENDRYCH, LEOS KREN, VACLAV VYBIHAL, HANA VALEKOVA, PETRA KASPAROVA, IVANA KOLOUSKOVA, TOMAS KAZDA, ONDREJ SLABY, RADIM JANCALEK, JIRI SANA, MARTIN SMRCKA
Cancer Genomics & Proteomics Jan 2023, 20 (1) 18-29; DOI: 10.21873/cgp.20361
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Keywords

  • Brain metastases
  • microRNA
  • small RNA sequencing
  • classifier
  • diagnosis
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