Article Figures & Data
Figures
- Figure 1.
Treatment schema. DOX: Doxorubicin; o-rMETase: oral recombinant methioninase; DAC: decitabine.
- Figure 2.
(A) Relative tumor volume of the USTS-PDOX model. (B)Waterfall plot of relative tumor volume. Six mice were in each group. *p=0.05; **p=0.01; ***p=0.001. Error bars: ±SEM. USTS, Undifferentiated/unclassified soft-tissue sarcoma; PDOX, patient-derived orthotopic xenograft; o-rMETase, oral recombinant methioninase; CL, cycloleucine; DOX, doxorubicin; DAC, decitabine; SEM, standard error of the mean.
- Figure 3.
(A) Representative photographs of treated USTS PDOX mouse models on day 14. Arrows show the margin of the tumors. (B) Bar graphs indicate relative tumor volume of each group on day 14. Scale bars: 10 mm. 6 mice were in each group. *p=0.05; **p=0.01; ***p=0.001. Error bars: ±SEM. USTS, Undifferentiated/unclassified soft-tissue sarcoma; PDOX, patient-derived orthotopic xenograft; o-rMETase, oral recombinant methioninase; CL, cycloleucine; DOX, doxorubicin; DAC, decitabine; SEM, standard error of the mean.
- Figure 4.
H&E staining. (A, A’) Control. (B, B’) CL alone. (C, C’) o-rMETase alone. (D, D’) DOX alone. (E, E’) CL+DAC. (F, F’) o-rMETase+CL+DAC. Scale bars: 100 μm. o-rMETase, oral recombinant methioninase; DOX, doxorubicin; CL, cycloleucine; DAC, decitabine.
- Figure 5.
Mouse body-weight. *p=0.05; **p=0.01; ***p=0.001. Error bars: ±SEM. o-rMETase, oral recombinant methioninase; CL, cycloleucine; DOX, doxorubicin; DAC, decitabine; SEM, standard error of the mean.
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