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Open Access

microRNAs and Corresponding Targets Involved in Metastasis of Colorectal Cancer in Preclinical In Vivo Models

ULRICH H. WEIDLE, ULRICH BRINKMANN and SIMON AUSLAENDER
Cancer Genomics & Proteomics September 2020, 17 (5) 453-468; DOI: https://doi.org/10.21873/cgp.20204
ULRICH H. WEIDLE
Large Molecule Research, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Munich, Penzberg, Germany
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  • For correspondence: weidle49@t-online.de simon.auslaender@roche.com
ULRICH BRINKMANN
Large Molecule Research, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Munich, Penzberg, Germany
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SIMON AUSLAENDER
Large Molecule Research, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Munich, Penzberg, Germany
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  • For correspondence: weidle49@t-online.de simon.auslaender@roche.com
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Article Information

vol. 17 no. 5 453-468
DOI 
https://doi.org/10.21873/cgp.20204
PubMed 
32859626

Published By 
International Institute of Anticancer Research
Print ISSN 
1109-6535
Online ISSN 
1790-6245
History 
  • Received June 15, 2020
  • Revision received July 8, 2020
  • Accepted July 17, 2020
  • Published online August 28, 2020.

Copyright & Usage 
Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved

Author Information

  1. ULRICH H. WEIDLE⇑,
  2. ULRICH BRINKMANN and
  3. SIMON AUSLAENDER⇑
  1. Large Molecule Research, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Munich, Penzberg, Germany
  1. Correspondence to: Ulrich H. Weidle and Simon Ausländer, Roche Innovation Center Munich, Roche Diagnostics GmbH, Im Nonnenwald 2, D-82372 Penzberg, Germany. Tel: +49 88566013901, email: weidle49{at}t-online.de (UHW), simon.auslaender{at}roche.com (SA)
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Cancer Genomics & Proteomics
Vol. 17, Issue 5
September-October 2020
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microRNAs and Corresponding Targets Involved in Metastasis of Colorectal Cancer in Preclinical In Vivo Models
ULRICH H. WEIDLE, ULRICH BRINKMANN, SIMON AUSLAENDER
Cancer Genomics & Proteomics Sep 2020, 17 (5) 453-468; DOI: 10.21873/cgp.20204

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microRNAs and Corresponding Targets Involved in Metastasis of Colorectal Cancer in Preclinical In Vivo Models
ULRICH H. WEIDLE, ULRICH BRINKMANN, SIMON AUSLAENDER
Cancer Genomics & Proteomics Sep 2020, 17 (5) 453-468; DOI: 10.21873/cgp.20204
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  • Article
    • Abstract
    • Metastasis of CRC
    • miRs and Their Role in Oncology
    • miRs Up-regulated in Metastatic Colon Cancer Cells
    • miRs Down-regulated in Metastatic Colon Cancer Cells
    • Therapeutic Aspects
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Keywords

  • Epithelial-mesenchymal transition (EMT)
  • invasion and migration
  • in vivo metastasis-related models
  • microRNA (miR)
  • miR-related therapeutic agents
  • liver metastasis
  • oncogenic signaling pathways
  • TGFβ signaling
  • tumor- and -metastasis suppressors
  • review
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