The Role of Circulating Adiponectin and SNP276G&gt;T at ADIPOQ Gene in BRCA-mutant Women

ANTONELLA DANIELE; ANGELO VIRGILIO PARADISO; ROSA DIVELLA; MARIA DIGENNARO; MARGHERITA PATRUNO; STEFANIA TOMMASI; BRUNELLA PILATO; ANTONIO TUFARO; MICHELE BARONE; CARLA MINOIA; DONATELLA COLANGELO; EUFEMIA SAVINO; PORZIA CASAMASSIMA; ELEONORA BRUNO; ANDREINA OLIVERIO; PATRIZIA PASANISI

doi:10.21873/cgp.20190

Abstract

Background: Environmental factors may influence the lifetime risk of cancer (penetrance) in women with a BRCA mutation. Materials and Methods: In 89 BRCA-mutant women, affected or unaffected by breast/ovarian cancer, we explored serum levels of adipokines and their relation with the polymorphism SNP276G>T as modulators of BRCA penetrance. Results: Affected women had significantly lower adiponectin than healthy women. Affected women with rs1501299 TT had significantly lower adiponectin and higher leptin than GT and GG genotypes. GT genotype was significantly associated with the disease status [odds ratio (OR)=3.24, 95% confidence interval (95% CI)=1.03-10.17]. Women in the lower tertile of serum adiponectin had a RR of BRCA-associated cancer of 2.80, 95% CI=1.1-7.1 (p for trend=0.03) compared with women in the higher tertile. Conclusion: In the SNP rs1501299 the T allele was significantly associated with lower serum levels of adiponectin in affected women, suggesting that the T allele might be related to cancer.

Footnotes

Authors' Contributions
Antonella Daniele: First and corresponding author of the paper, design study, nutritional evalutation of patients, practical performance, data analysis, preparation of manuscript; Angelo Virgilio Paradiso, Maria Digennaro and Margherita Patruno: patients recruitment and oncological evaluation; Rosa Divella and Antonio Tufaro: biological bank; Stefania Tommasi and Brunella Pilato: genetic analyses; Michele Barone: writing and editing; Carla Minoia: writing and editing; Donatella Colangelo, Eufemia Savino and Porzia Casamassima: biochemical blood profile; Eleonora. Bruno and Andreina Oliverio: data analyses; Patrizia Pasanisi: principal investigator of the study, author of the paper and contribution to data analyses;
This article is freely accessible online.
Conflicts of Interest
The Authors have no conflicts of interest to declare regarding this study.
Funding
The study was funded by the Italian Cancer Research Association (AIRC) grant n. IG-2015-17151 and by the Italian Ministry of Health grant n. GR-2010-2310116.