Article Figures & Data
Figures
- Figure 1.
Structure of CDDP and 3Pt (10).
- Figure 2.
Growth-inhibition assay. Growth-inhibition of patient-derived osteosarcoma AC-OS01 calls treated with CDDP (A) or 3Pt (B). Cells were incubated with each drug for 72 h and then growth was assessed with the WST-8 method.
- Figure 3.
In vivo antitumor efficacy of CDDP and 3Pt on osteosarcoma PDOX mouse model. (A) Treatment protocol (B) Osteosarcoma was grown orthotopically in the right distal femur of nude mice and allowed to form tumors. Mice were treated with CDDP, 3Pt. [CDDP (20 μmol/kg=6 mg/kg/week i.p. for 2 weeks], or 3Pt (15 μmol/kg=41.1 mg/kg/week i.p. for 2 weeks). Tumor volume was measured at the indicated time points after the onset of treatment. N=8 mice/group. *p=0.0004, **p=0.0002.
- Figure 4.
Body weight. Bar graphs show body weight in each group at pre-treatment and 2 weeks after initiation of drug administration. There were no significant differences between any group. n.s.: no significant difference.
- Figure 5.
Tumor histology. H & E-stained sections of the untreated PDOX tumor (A), PDOX tumor treated with CDDP (B), PDOX tumor treated with 3Pt (C). White scale bars: 80 μm.
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