Article Figures & Data
Figures
- Figure 1.
In chromosome 20p12.1, a poliovirus sequence with almost 100% identity, consisting of a sense and an antisense strand of 32 nucleotides (6380 to 6411), which codes for the 3Dpol, an RNA dependent RNA polymerase whose function is to make multiple copies of the viral RNA genome. The viral sequence is in an intronic region of the MACROD2 gene, indicated by the dashed lines of Gencode. Red line: Genome and poliovirus sequence have different bases at this position. Green line: The poliovirus sequence appears to have a polyA tail that is not aligned to the genome (https://genome.ucsc.edu).
- Figure 2.
Colon adenoma stained with HPA049076 anti-MACROD2 antibody produced in rabbit (Human Protein Atlas available from www.proteinatlas.org).
- Figure 3.
In chromosome 1p13.3 a poliovirus sequence with 89.3% identity, consisting of a sense and an antisense strand of 28 nucleotides, 811 through 838, which code for the VP4 protein of the viral capsid. The viral sequence is within an intronic region of the solute carrier family 25 member 24 gene (SLC25A24). Red line: Genome and poliovirus sequence have different bases at this position. Green line: The poliovirus sequence appears to have a polyA tail that is not aligned to the genome (https://genome.ucsc.edu).
- Figure 4.
Increased RNA expression of the SLC25A24 gene poliovirus sequence on chromosome 1p13.3 was associated with significantly increased survival in colorectal cancer patients.
- Figure 5.
In chromosome 2p25.1, a poliovirus sequence with almost 100% identity, consisting of two sense strands, 20 nucleotides, 7106 through 7125, which codes for the 3Dpol. Red line: Genome and poliovirus sequence have different bases at this position (https://genome.ucsc.edu).
- Figure 6.
Analysis of the COAD (adenocarcinoma of the colon) cohort in TCGA: relationship of PVR, the poliovirus cellular receptor, to FCAR, a gene that encodes a receptor for the Fc region of Immunoglobulin A. There is a significant correlation in copy number alterations of both genes. Number of cases in each box (http://www.cbioportal.org).
- Figure 7.
Polio incidence in 48 states (1937-1951) versus colorectal cancer deaths per 100,000 (2005-2009). The correlation was significant for men (A: r=−0.493, p<0.0005) and women (B: r=−0.440, p=0.002). Alaska and Hawaii were not States in 1951.
