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Research Article
Open Access

A Proteomic Analysis of the Malignant Mesothelioma Secretome Using iTRAQ

JENETTE CREANEY, IAN M. DICK, JUSTINE S. LEON and BRUCE W.S. ROBINSON
Cancer Genomics & Proteomics March 2017, 14 (2) 103-117;
JENETTE CREANEY
1National Centre for Asbestos Related Diseases, School of Medicine and Pharmacology, University of Western Australia and Australian Mesothelioma Tissue Bank, Sir Charles Gairdner Hospital, Perth, Western Australia
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  • For correspondence: jenette.creaney@uwa.edu.au
IAN M. DICK
2National Centre for Asbestos Related Diseases, School of Medicine and Pharmacology, University of Western Australia, Sir Charles Gairdner Hospital, Perth, Western Australia
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JUSTINE S. LEON
2National Centre for Asbestos Related Diseases, School of Medicine and Pharmacology, University of Western Australia, Sir Charles Gairdner Hospital, Perth, Western Australia
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BRUCE W.S. ROBINSON
2National Centre for Asbestos Related Diseases, School of Medicine and Pharmacology, University of Western Australia, Sir Charles Gairdner Hospital, Perth, Western Australia
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Abstract

Backgound/Aim: Malignant mesothelioma (MM) is an aggressive and fatal pleural cancer. The cell secretome offers information allowing insight into the pathogenesis of MM while offering the possibility to identify potential therapeutic targets and biomarkers. In the present study the secretome protein profile of MM cell lines was compared to normal mesothelial cells. Materials and Methods: Six MM cell lines were compared against three primary mesothelial cell culture preparations using iTRAQ® mass spectrometry. Results: MM cell lines more abundantly secreted exosome-associated proteins than mesothelial cells. MM cell secretomes were enriched in proteins that are involved in response to stress, carbon metabolism, biosynthesis of amino acids, antigen processing and presentation and protein processing in the endoplasmic reticulum. Conclusion: The MM cell secretome is enriched in proteins that are likely to enhance its growth and response to stress and help it inhibit an adaptive immune response. These are potential targets for therapeutic and biomarker discovery.

  • Malignant mesothelioma
  • proteomics
  • iTRAQ
  • secretome
  • Received January 18, 2017.
  • Revision received February 28, 2017.
  • Accepted February 28, 2017.
  • Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved

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Cancer Genomics & Proteomics
Vol. 14, Issue 2
March-April 2017
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A Proteomic Analysis of the Malignant Mesothelioma Secretome Using iTRAQ
JENETTE CREANEY, IAN M. DICK, JUSTINE S. LEON, BRUCE W.S. ROBINSON
Cancer Genomics & Proteomics Mar 2017, 14 (2) 103-117;

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A Proteomic Analysis of the Malignant Mesothelioma Secretome Using iTRAQ
JENETTE CREANEY, IAN M. DICK, JUSTINE S. LEON, BRUCE W.S. ROBINSON
Cancer Genomics & Proteomics Mar 2017, 14 (2) 103-117;
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Keywords

  • Malignant mesothelioma
  • proteomics
  • ITRAQ
  • secretome
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